蛋白激酶Cε过量表达与乳腺癌临床病理特征的关系

Association of overexpression of PKCε with clinicopathological features of breast cancer

目的探讨蛋白激酶Cε(protein kinase C epsilon,PKCε)在乳腺组织中的表达及其过量表达与浸润性乳腺癌临床病理特征的关系。方法采用免疫组化法检测正常乳腺组织(33例)、导管原位癌(26例)及浸润性乳腺癌(126例)中PKCε的表达情况,分析其表达水平与乳腺癌临床病理特征的关系。结果PKCε在乳腺浸润性癌中的表达高于其在正常乳腺(P<0.05)和导管原位癌组织(P<0.05)中的表达,且与乳腺癌的组织学类型相关(P<0.05)。PKCε的过量表达与乳腺癌是否发生淋巴结转移、组织学分级、PR和HER2的表达相关(P<0.05),与患者年龄、癌灶大小、TNM分期、Ki67指数及ER的表达无显著相关(P>0.05)。结论PKCε的过量表达与乳腺癌的发生、转移及不良预后密切相关,检测PKCε的表达水平可作为乳腺癌预后判断的独立指标。

Objective To investigate the association of the expression and overexpression of protein kinase C epsilon(PKCε)in breast tissue with clinicopathological features of invasive breast cancer.Methods Immunohistochemistry was used to detect the expression of PKCεin normal breast tissue(n=33),ductal carcinoma in situ(n=26)and invasive breast cancer(n=126).and the clinicopathological characteristics of breast cancer were analyzed.Results The expression of PKCεin invasive breast cancer was higher than that in normal breast tissue(P<0.05)and ductal carcinoma in situ(P<0.05),and the expression level was correlated with the histological type of breast cancer(P<0.05).Over expression of PKCεwas correlated with lymph node metastasis,histological grade,PR and HER2 expression(P<0.05),but not significantly with age,tumor size,TNM stage,Ki67 index and ER expression(P<0.05).Conclusion The overexpression of PKCεwas closely related to the occurrence,metastasis and poor prognosis of breast cancer.Detection of the expression of PKCεcould be used as an independent prognostic indicator of breast cancer.