银杏内酯注射液对急性脑梗死患者血小板活化状态的影响

Effect of Ginkgolide Injection on platelet activation in patients with acute cerebral infarction

目的探讨银杏内酯注射液对急性脑梗死(ACI)患者血小板活化状态的影响。方法选择2016年1月~2018年1月南昌大学第二附属医院诊治的112例ACI患者作为研究对象进行回顾性分析,按照治疗方法的不同,分为对照组和治疗组,每组56例。对照组给予阿司匹林治疗,治疗组给予银杏内酯注射液治疗。比较两组患者治疗前后血小板膜糖蛋白(PAC-1)和P选择素(CD62P)的水平。分析两组患者主要不良心脑血管事件的发生情况。结果治疗组的临床治疗总有效率为96.43%,高于对照组的80.36%,差异有统计学意义(P<0.05)。治疗前,两组患者的PAC-1和CD62P水平比较,差异无统计学意义(P>0.05);治疗后,两组患者的PAC-1和CD62P水平低于治疗前,治疗组的PAC-1和CD62P水平显著低于对照组,差异均有统计学意义(P<0.05)。治疗组的主要不良心血管事件总发生率为3.57%,低于对照组的14.29%,差异有统计学意义(P<0.05)。结论银杏内酯注射液可明显提高ACI患者临床疗效,改善血小板活化状态,有效防止血栓形成,降低主要不良心血管事件发生。

Objective To investigate the effect of Ginkgolide Injection on platelet activation in patients with acute cerebral infarction(ACI).Methods A total of 112 patients with ACI treated in the Second Affiliated Hospital of Nanchang University from January 2016 to January 2018 were selected as the study subjects for retrospictive analysis.According to the different treatment methods,they were divided into the control group and the treatment group,56 cases in each group.The control group was treated with Aspirin and the treatment group was treated with Ginkgolide Injection.The levels of platelet membrane glycoprotein(PAC-1)and cluster of differentiation 62 platelet(CD62P)were compared between the two groups before and after treatment.The main adverse cardiovascular and cerebrovascular events in the two groups were analyzed.Results The total effective rate of the treatment group was 96.43%,which was higher than that of the control group(80.36%),the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in PAC-1 and CD62P levels between the two groups(P>0.05);after treatment,the levels of PAC-1 and CD62P in the two groups were lower than those before treatment,and the levels of PAC-1 and CD62P in the treatment group were lower than those in the control group,the differences were statistically significant(P<0.05).The total incidence of major adverse cardiovascular events in the treatment group was 3.57%,which was lower than that in the control group(14.29%),the difference was statistically significant(P<0.05).Conclusion Ginkgolides Injection can significantly improve the clinical efficacy of ACI patients,improve platelet activation,effectively prevent thrombosis and reduce the major adverse cardiovascular events.