住院患者耐甲氧西林金黄色葡萄球菌的感染与耐药分析

Infection and Drug Resistance Analysis of Methicillin-resistant Staphylococcus Aureus in Hospitalized Patients

目的探究住院患者耐甲氧西林金黄色葡萄球菌的感染与耐药性情况。方法选取该院2017年1月—2018年12月接收的住院患者金黄色葡萄球菌阳性的所有临床标本共453例,有多重耐药菌95例,其中62例为耐甲氧西林金黄色葡萄球菌,对其中62例耐甲氧西林金黄色葡萄球菌标本进行检验,将其耐甲氧西林金黄色葡萄球菌的感染与耐药性进行分析。结果2017年和2018年这2年住院患者金黄色葡萄球菌阳性的453份标本中,分离出多重耐药的金黄色葡萄球菌95例,其中62例为耐甲氧西林金黄色葡萄球菌,构成比显著较高,为65.26%(62/95),而对利奈唑胺、替考拉宁、万古霉素和替加环素比较敏感。结论住院患者耐甲氧西林金黄色葡萄球菌具有较高耐药率,临床必须要严格地执行消毒隔离制度,及时检测耐药菌,进而有效防控感染和耐药。

Objective To investigate the infection and drug resistance of methicillin-resistant Staphylococcus aureus in hospitalized patients.Methods A total of 453 clinical specimens of Staphylococcus aureus positive in hospitals received from January 2017 to December 2018 were enrolled in our hospital.There were 95 cases of multi-drug resistant bacteria,of which 62 were methicillin-resistant golden yellow grapes cocci,62 cases of methicillin-resistant Staphylococcus aureus specimens were tested,and the infection and drug resistance of methicillin-resistant Staphylococcus aureus were analyzed.Results Of the 453 specimens of S.aureus positive in hospitalized patients in 2017 and 2018,95 were multidrug-resistant Staphylococcus aureus,62 of which were methicillin-resistant Staphylococcus aureus,significantly higher,65.26%(62/95),but sensitive to linezolid,teicoplanin,vancomycin and tigecycline.Conclusion Inpatients with methicillin-resistant Staphylococcus aureus have high drug resistance rate.It is necessary to strictly implement the disinfection and isolation system in clinical practice,and timely detect drug-resistant bacteria,so as to effectively prevent infection and drug resistance.