阻塞性睡眠呼吸暂停综合征患者血清小而密低密度脂蛋白水平

The effect of sdLDL in patients with OSAHS

目的 探讨阻塞性睡眠呼吸暂停综合征(OSAHS)患者血清小而密低密度脂蛋白(sdLDL)水平改变及临床意义。方法 收集该院163例OSAHS患者,分为轻中重3组,选择同期体检健康者66例为对照组。所有受试者采用多导睡眠脑电监测仪(PSG)进行睡眠脑电监测,并测定外周血sdLDL的含量。结果 OSAHS患者sdLDL较对照组明显升高,且不同程度的OSAHS组间比较差异有统计学意义。结论 OSAHS患者sdLDL明显升高,且与OSAHS的程度有关,在OSAHS患者动脉粥样硬化疾病的发生发展中可能起一定作用。

Objective To evaluate the effect of small dense low-density lipoprotein(sdLDL)in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS).Methods A total of 163 patients with OSAHS were enrolled in the study,and were divided into three groups.66 healthy people were selected as the control group.All subjects were monitored by PSG,and the expression of sdLDL was detected.Results The expression of sdLDL in patients with OSAHS increased significantly compared to the control group,and the difference between OSAGH groups was statistically significant.Conclusion The expression of sdLDL in patients with OSAHS increased significantly and related to the degree of OSAHS.It may play a role in the occurrence and development of cardiovascular and cerebrovascular disease in patients with OSAGH.