中性粒细胞与肿瘤：是敌是友？

Neutrophils and Tumor:Foes or Friends?

肿瘤的进展不仅与肿瘤细胞本身有关,还与其他相关的参与者有关,包括癌细胞募集的免疫细胞、免疫细胞释放的促炎因子和细胞外基质。这些分子构成了肿瘤的微环境,在肿瘤的发生发展中起着重要的作用。中性粒细胞通常被认为对肿瘤细胞有防御反应,但最近的证据表明肿瘤调节中性粒细胞功能以支持肿瘤生长和发展,在肿瘤的进展和转移中起着积极的作用,是肿瘤微环境的重要组成部分。中性粒细胞可能被认为是多种肿瘤类型的新靶点之一。本文对中性粒细胞在肿瘤微环境中的抗癌活性与促癌活性的最新进展,以及以中性粒细胞为靶点的潜在治疗策略的发展前景作以下综述。

Tumor progression is not only related to tumor cells themselves,but also to other relevant participants,including immune cells recruited by tumor cells,pro-inflammatory factors released by immune cells and extracellular matrix.These molecules constitute the microenvironment of tumor and play an important role in the occurrence and development of tumor.Neutrophils are generally considered to have a defensive response to tumor cells,but recent evidence shows that tumor regulation of neutrophil function can support tumor growth and development and play an active role in tumor progression and metastasis.it is an important part of tumor microenvironment.Neutrophils may be considered as one of the new targets for many types of cancer.This article reviews the latest progress in the anticancer and tumor-promoting activity of neutrophils in tumor microenvironment,as well as the development prospect of potential therapeutic strategies targeting neutrophils.