白芍总苷胶囊联合硫酸羟氯喹治疗干燥综合征的临床效果

Clinical effect of Total Glycosides of Paeony Capsules combined with Hydroxychloroquine Sulfate in the treatment of Sjogren′s syndrome

目的探讨白芍总苷胶囊联合硫酸羟氯喹治疗干燥综合征(SS)的临床效果。方法选择2015年9月~2019年3月于安徽医科大学附属安庆医院收治的100例SS患者,按照随机数字表法分为对照组(50例)和观察组(50例)。对照组给予硫酸羟氯喹治疗,观察组给予白芍总苷胶囊联合硫酸羟氯喹治疗,两组均治疗3个月。评价并比较两组临床疗效,比较两组治疗前后口干、眼干、发热、关节痛评分及红细胞沉降率(ESR)、免疫球蛋白G(IgG)、C反应蛋白(CRP)水平。记录两组治疗过程中不良反应发生情况。结果观察组的临床总有效率明显高于对照组,差异有统计学意义(P<0.05)。两组治疗后口干、眼干、发热评分及关节痛评分均明显低于治疗前(P<0.05),且观察组明显低于对照组,差异有统计学意义(P<0.05)。两组治疗后ESR、IgG及CRP水平均明显低于治疗前(P<0.05),且观察组明显低于对照组,差异有统计学意义(P<0.05)。治疗期间,两组不良反应发生率比较差异无统计学意义(P>0.05)。结论白芍总苷胶囊联合硫酸羟氯喹治疗SS的临床效果显著,能够明显改善临床症状,且安全性较好。

Objective To investigate clinical effect of Total Glucosides of Paeony Capsules combined with Hydroxy-chloroquine Sulfate in the treatment of Sjogren′s syndrome(SS).Methods One hundred SS patients admitted to Anqing Hospital Affiliated to Anhui Medical University from September 2015 to March 2019 were divided into control group(50 cases)and observation group(50 cases)according to random number table method.Control group was treated with Hydroxychloroquine Sulfate,while observation group was treated with Total Glucosides of Paeony Capsules combined with Hydroxychloroquine Sulfate.Both groups were treated for 3 months.Clinical effect of two groups was evaluated and compared.The dry mouth score,dry eye score,fever score,joint pain score,erythrocyte sedimentation rate(ESR),immunoglobulin G(IgG)and C reactive protein(CRP)level were compared between two groups before and after treat-ment.The occurrence of adverse reactions during the treatment was recorded.Results Total clinical effective rate of observation group was significantly higher than that of control group,there was a significant difference between two groups(P<0.05).After treatment,the scores of dry mouth,dry eye,fever and joint pain in two groups were significant-ly lower than those before treatment(P<0.05),while scores of dry mouth,dry eye,fever and joint pain in observation group were significantly lower than those in control group(P<0.05).ESR,IgG and CRP in two groups were significant-ly lower than those before treatment(P<0.05),while ESR,IgG and CRP in observation group were significantly lower than those in control group(P<0.05).During the treatment period,there was no significant difference between two groups(P>0.05).Conclusion Total Glucosides of Paeony Capsules combined with Hydroxychloroquine Sulfate in the treatment of SS has significant clinical efficacy,which can significantly improve clinical symptoms,and has good safety.