肝细胞癌的免疫细胞治疗研究进展

Research progress in immune cell therapy for hepatocellular carcinoma

肝细胞癌是全球常见恶性肿瘤之一,在中国尤为高发。目前肝细胞癌的治疗手段主要有手术、放射治疗、局部消融治疗、肝动脉化疗栓塞、分子靶向治疗等。由于肝细胞癌起病隐匿,大多数患者发现时已失去手术时机,治疗效果十分有限,因此探索新的治疗方案具有重要意义。肿瘤免疫细胞疗法是目前最受关注的新兴治疗手段,尤其是基因修饰的T细胞疗法在肝细胞癌的治疗中显示出巨大的潜能。本文将综述免疫细胞治疗在肝细胞癌中的最新研究进展。

Hepatocellular carcinoma is one of the most common malignant tumors in the world,especially in China with the highest morbidity.Currently,hepatocellular carcinoma is mainly treated by surgery,radiotherapy,local ablation,hepatic artery chemoembolization,molecular targeted therapy,etc.Because of the occult onset of hepatocellular carcinoma,most patients have lost the opportunity for surgery when they are discovered,and the therapeutic effect is very limited.Therefore,it is of great significance to explore new treatment options.Tumor immune cell therapy is currently the most concerned emerging treatment,especially gene modified T cell therapy has shown great potential in the treatment of hepatocellular carcinoma.This paper will review the recent advances in immunotherapy for hepatocellular carcinoma.