黄体酮联合间苯三酚对先兆流产患者SOCS3表达及围生儿结局的影响

Effect of Progesterone combined with Phloroglucin on the expression of SOCS3 and perinatal outcome in threatened abortion

目的 探究黄体酮联合间苯三酚治疗对先兆流产患者细胞因子信号转导负调控因子3(SOCS3)表达水平和治疗后围生儿结局的影响。方法 选取2015年6月~2017年6月新疆医科大学第一附属医院妇科收治的先兆流产患者94例,依据随机数表法将其分成观察组和对照组,每组47例。对照组给予黄体酮治疗,观察组在对照组基础上加用间苯三酚,比较两组临床效果、SOCS3 mRNA水平、SOCS3蛋白水平;统计妊娠期高血压、胎盘早剥、胎盘前置、胎盘早破、妊娠期糖尿病的发生情况及新生儿畸形、足月低体重儿、早产儿、新生儿死亡、1 min Apgar评分等。结果 观察组有效率高于对照组,差异有统计学意义(P <0.05)。治疗1周后,观察组SOCS3 m RNA及蛋白质水平显著高于对照组,差异有统计学意义(P <0.05)。两组妊娠期高血压、胎盘早剥、胎盘前置、胎盘早破、妊娠期糖尿病发生情况比较,差异无统计学差异(P> 0.05)。两组新生儿畸形、足月低体重儿、早产儿、新生儿死亡率及1 min Apgar评分比较,差异无统计学意义(P> 0.05)。结论 黄体酮联合间苯三酚治疗先兆流产可显著提高患者机体SOCS3水平,临床效果显著,不增加妊娠期并发症及围产儿不良结局。

objective To explore the effect of Progesterone combined with Phloroglucin on the expression suppressors of cytokine signaling 3(SOCS3)and perinatal outcome in threatened abortion.Methods From June 2015 to June 2017,94 cases with threatened abortion treated in Department of Gynecology,the First Affiliated Hospital,Xinjiang Medical University were seleted.According to random number table method,they were divided into the observation group and the control group,with 47 cases in each group.The control group was treated with Progesterone,while the observation group was added with Phloroglucin on the basis of the control group.The clinical treatment effect and the expression levels of SOCS3 of two groups were compared.The incidence of gestational hypertension,placental abruption,placental previa,placental premature rupture,gestational diabetes,neonatal malformation,full-term low birth weight,premature birth,neonatal death,and 1 min Apgar score were also recorded.Results The clinical treatment effect of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).One week after treatment,the mRNA and protein levels of SOCS3 in the observation group were significantly higher than those in the control group,with the differences were statistically significant(P<0.05).There were no significant differences in the incidence of gestational hypertension,placental abruption,placental previa,placental premature rupture and gestational diabetes between the two groups(P>0.05).There were no statistically significant differences between the two groups in neonatal malformation,full-term low birth weight,premature birth,neonatal death,and 1 min Apgar score(P>0.05).Conclusion Progesterone combined with Phloroglucin in the treatment of threatened abortion clinical effect is significant,which can significantly improve the patients′SOCS3 level and no adverse perinatal outcomes.