中药阻断NF-κB信号通路抑制Ⅰ型单纯疱疹病毒感染的研究进展

Advances in blocking NF-κB signaling pathway with traditional Chinese medicine to inhibit herpes simplex virus type Ⅰ infection

核转录因子-κB(NF-κB)是诱导抗病毒基因表达的重要转录因子,通过调控多种靶基因的表达在氧化应激、细胞凋亡、炎症等生理病理过程中起到重要作用。Ⅰ型单纯疱疹病毒(HSV-1)是一种广泛传播的病毒,可在世界范围内引起多种疾病。耐药株的出现增加了研发新型抗病毒药物的紧迫性,而药用植物及其提取物作为抗病毒药物越来越受到人们的关注。本文主要综述了HSV-1潜伏感染及复发的机制、HSV-1感染引发NF-κB激活机制及不同中药阻断NF-κB信号通路抑制HSV-1感染机制,以期为抗HSV-1的新药研发及控制病毒所致疾病提供参考依据。

Nuclear transcription factor-κB(NF-κB) is an important transcription factor that induces antiviral gene expression and plays an important role in physiological and pathological processes such as oxidative stress, apoptosis and inflammation by regulating the expression of multiple target genes. Herpes simplex virus type Ⅰ(HSV-1) is a widely spread virus, caused a variety of diseases worldwide. The emergence of drug-resistant strains has increased the urgency of developing new antiviral drugs, and medicinal plants and their extracts have attracted more and more attention as antiviral drugs. This article mainly summarizes the mechanism of latent infection and recurrence of HSV-1, the mechanism of NF-κB activation induced by HSV-1 infection and different traditional Chinese medicine blocking the NF-κB signaling pathway inhibition HSV-1 mechanisms, in order to against the new drug research and development and control of HSV-1 virus caused by the disease provide a reference basis.