支气管哮喘患者细胞间黏附因子-1、嗜酸粒细胞的水平变化及临床意义

Changes and clinical significance of intercellular adhesion molecule-1 and eosinophils levels in patients with bronchial asthma

目的探究支气管哮喘患者细胞间黏附因子-1(ICAM-1)、嗜酸性粒细胞(EOS)水平变化及临床意义。方法选择2012年1月~2017年12月于南京脑科医院(以下简称"我院")就诊的支气管哮喘患者86例,根据患者病情及症状将其分为急性发作组(45例)和缓解组(41例),选择同期于我院进行健康检查人群52名作为对照组。比较三组患者血清ICAM-1、EOS水平及肺功能指标,并分析相关性。结果支气管哮喘急性发作组与缓解组ICAM-1与EOS水平明显高于对照组,且急性发作组高于缓解组(P <0.05);支气管哮喘急性发作组与缓解组每分钟最大通气量(MVV)/预计值、呼气峰流速值(PEF)、第1秒用力呼气容积(FEV1)及用力肺活量(FVC)均低于对照组,且急性发作组低于缓解组(P <0.05)。Spearman相关性分析结果显示,支气管哮喘患者ICAM-1、EOS水平与FVC、FEV1呈负相关(r=-0.652,-0.548;r=-0.549,-0.598,均P <0.05)。结论 ICAM-1与EOS可能参与支气管哮喘发生、发展过程,分析ICAM-1含量与EOS计数变化对于支气管哮喘病情诊断与治疗具有重要的临床意义。

Objective To investigate the changes and clinical significance of intercellular adhesion molecule-1(ICAM-1) and eosinophils(EOS) in patients with bronchial asthma. Methods From January 2012 to December 2017, a total of86 patients with bronchial asthma treated in Nanjing Brain Hospital("our hospital" for short) were divided into acute attack group(45 cases) and remission group(41 cases) according to their condition and symptoms. A total of 52 people undergoing health examination in our hospital at the same time were selected as control group. The levels of serum ICAM-1, EOS and pulmonary function were compared among the three groups, and the correlation was analyzed. Results The level of ICAM-1 and EOS in acute attack group and remission group were significantly higher than those in control group, while acute attack group was significantly higher than remission group, and the differences were statistically significant(P < 0.05). Maximal voluntary ventilation(MVV)/predicted value, peak expiratory flow(PEF), one second forced breath volume(FEV1) and forced vital capacity(FVC) in acute attack group and remission group were lower than those in control group, while those in acute attack group were lower than those in remission group, and the differences were statistically significant(P < 0.05). Spearman correlation results showed that ICAM-1, EOS levels were negatively correlated with FVC, FEV1 in patients with bronchial asthma(r =-0.652,-0.548;r =-0.549,-0.598, P <0.05). Conclusion ICAM-1 and EOS may be involved in the occurrence and development of bronchial asthma. The analysis of ICAM-1 content and EOS count have important clinical significance for the diagnosis and treatment of bronchial asthma.