壮方柔肝化纤颗粒治疗肝肾阴虚型乙肝肝硬化腹水的效果

Effect of Zhuangfang Ruogan Huaxian Granules in the treatment of ascites due to hepatitis B cirrhosis with syndrome of liver-kidney yin deficiency

目的观察壮方柔肝化纤颗粒治疗肝肾阴虚型乙肝肝硬化腹水的效果。方法选取2017年2月~2019年2月于广西中医药大学第一附属医院及广西国际壮医医院肝病科确诊为肝肾阴虚型乙肝肝硬化腹水患者70例,按随机数字表法将其分为对照组和观察组,每组35例。对照组采取内科常规治疗,观察组在对照组的基础上采用壮方柔肝化纤颗粒。比较两组治疗后的总有效率及治疗前后的中医证候积分、肝功能指标、体重、腹围及24 h尿量。结果观察组的临床总有效率高于对照组,差异有统计学意义(P <0.05)。两组治疗后的黄疸、食欲减退、腹胀腹泻、肝脾肿大积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P <0.05)。两组治疗后的谷草转氨酶、谷丙转氨酶、总胆红素水平均低于治疗前,白蛋白水平高于治疗前,且观察组改善较对照组显著,差异有统计学意义(P <0.05)。与治疗前比较,两组治疗后体重降低,腹围减小,24 h尿量增加,且观察组改善较对照组显著,差异有统计学意义(P <0.05)。结论壮方柔肝化纤颗粒治疗肝肾阴虚型乙肝肝硬化腹水能明显提高患者的治疗效果,改善肝功能及生存质量,值得借鉴。

Objective To observe effect of Zhuangfang Ruogan Huaxian Granules in the treatment of ascites due to hepatitis B cirrhosis with syndrome of liver-kidney yin deficiency. Methods From February 2017 to February 2019,70 patients with hepatitis B cirrhosis ascites with syndrome of liver-kidney yin deficiency were selected from the First Affiliated Hospital of Guangxi University of Chinese Medicine and Hepatology Department of Guangxi International Zhuang Medical Hospital. They were divided into control group and observation group according to the random number table method, with 35 cases in each group. Control group received routine medical treatment, while observation group received Zhuangfang Ruogan Huaxian Granule on the basis of control group. Total effective rate after treatment, traditional Chinese medicine syndrome score, liver function index, body mass, abdominal circumference and 24 h urine volume before and after treatment were compared between two groups. Results Total clinical effective rate of observation group was higher than that of control group(P < 0.05). The scores of jaundice, anorexia, abdominal distention, diarrhea,hepatosplenomegaly in two groups after treatment were lower than those before treatment, observation group was lower than control group, and the differences were statistically significant(P < 0.05). The levels of AST, ALT and TBIL in two groups after treatment were lower than those before treatment, and the level of ALB in observation group after treatment was higher than that before treatment, and the improvement in observation group was more significant than that in control group, and the differences were statistically significant(P < 0.05). Compared with those before treatment, body mass in the two groups decreased, abdominal circumference reduced, and 24 h urine volume increased after treatment, and the improvement in observation group was more significant than that in control group, and the differences were statistically significant(P < 0.05). Conclusion Zhuangfang Ruogan Huaxian Granules can obviously improve the therapeutic effect and improve the liver function and quality of life of patients with ascites due to hepatitis B cirrhosis with syndrome of liver-kidney yin deficiency.