吡格列酮联合来曲唑在多囊卵巢综合征性排卵障碍患者中的应用效果分析

Application effects of pioglitazone combined with letrozole in ovulation failure patients caused by polycystic ovarian syndrome

目的:探讨吡格列酮联合来曲唑在多囊卵巢综合征(PCOS)性排卵障碍患者中的应用效果。方法:将92例PCOS性排卵障碍患者随机分为试验组(n=46)与对照组(n=46)。给予对照组患者来曲唑治疗,给予试验组患者吡格列酮联合来曲唑治疗,比较两组临床疗效、排卵率、妊娠率、流产率、激素水平[促卵泡成熟激素(FSH)、促黄体生成素(LH)、睾酮(T)、雌二醇(E2)]。结果:与对照组相比,试验组治疗总有效率、排卵率、妊娠率均更高,流产率更低;治疗后,两组FSH、LH、T、E2水平均明显下降,且试验组下降幅度相对更大,上述差异均具有统计学意义(P<0.05)。结论:吡格列酮联合来曲唑治疗PCOS性排卵障碍疗效确切,可有效调节患者体内激素水平,同时提高患者排卵率与妊娠率。

Objective To investigate the application effects of pioglitazone combined with letrozole in ovulation failure patients caused by polycystic ovarian syndrome(PCOS).Method 92 ovulation failure patients were randomly divided into experimental group(n=46)and control group(n=46).Control group was given letrozole,while experimental group was treated with pioglitazone and letrozole.The clinical efficacy,ovulation rate,pregnancy rate,abortion rate,hormone levels[follicle stimulating hormone(FSH),luteinizing hormone(LH),testosterone(T),estradiol(E2)]were compared between the two groups.Results Compared with control group,the total effective rate,ovulation rate and pregnancy rate of experimental group were higher,while the abortion rate of experimental group was lower;After treatment,the levels of FSH,LH,T,E2 in the two groups decreased,and the decreased range of experimental group was larger,and the above difference was statistically significant(P<0.05).Conclusion Pioglitazone combined with letrozole in treatment of ovulation failure caused by PCOS is effective,it can regulate the hormone levels,increase the ovulation rate and pregnancy rate.