经鼻双水平正压通气治疗极低出生体重早产儿呼吸暂停综合征的临床疗效观察

Observation of the curative effect of bi-level positive airway pressure in the treatment of apnea of very low birth weight premature infants

目的:探讨经鼻双水平正压通气(BiPAP)在极低出生体重早产儿呼吸暂停综合征中的临床应用效果。方法:选取极低出生体重早产儿呼吸暂停综合征患儿62例作为研究对象,随机分为观察组和对照组,各组31例。两组均给予常规治疗,在此基础上观察组给予经鼻双水平正压通气模式(BiPAP)治疗,对照组给予经鼻持续正压通气模式(CPAP)治疗。观察两组临床效果,比较治疗前、治疗第1天、第3天血氧分压、血二氧化碳分压、pH值。结果:观察组治疗总有效率93.5%(29/31),高于对照组74.2%(23/31),差异有统计学意义(P<0.05)。治疗第1天、治疗第3天血氧分压、血二氧化碳分压、pH值改善情况比对照组好,差异有统计学意义(P<0.05);观察组与对照组发生气漏综合征(3.2%比3.2%)、支气管肺发育不良(3.2%比6.5%)、脑室内出血(IVH)(3.2%比3.2%),两组差异无统计学意义(P>0.05)。结论:经鼻双水平正压通气治疗极低出生体重早产儿呼吸暂停综合征患儿效果显著,具有较高临床应用价值。

Objective To explore the clinical application effect of bi-level positive airway pressure(BiPAP)in the treatment of apnea of very low birth weight premature infants.Method 62 cases of very low birth weight premature infants with apnea syndrome were selected as the study subjects.They were randomly divided into observation group and control group,31 cases in each group.Two group was given normal treatment.On this basis,the observation group was treated with BiPAP,while the control group was treated with CPAP.Two groups of clinical therapeutic effect was observed,and compared before treatment,1 d,3 d treatment the blood oxygen partial pressure,blood Carbon dioxide partial pressure and pH value.Results The effective rate of the observation group(93.5%,29/31)was higher than that of the control group(74.2%,23/31),the difference was statistically significant(P<0.05).The blood oxygen partial pressure,blood partial pressure and pH value of the observation group were better than those of the control group at 1 d and 3 d(P<0.05).There was no significant difference between the observation group and the control group in the occurrence of air leak syndrome(3.2%vs 3.2%),bronchopulmonary dysplasia(3.2%vs 6.5%)and intraventricular hemorrhage(3.3%vs 3.3%)(P>0.05).Conclusion Bi-level positive airway pressure in the treatment of very low birth weight premature apnea syndrome effect is remarkable,has high clinical value.