硫酸寡糖锌促进小鼠生长发育及抗氧化作用

Zinc-sulfated Oligosaccharide Improving Growth and Antioxidant for Mice

为改善缺锌导致的生长发育缓慢,以麒麟菜为原料提取多糖,制备硫酸寡糖锌配合物,与硫酸锌、葡萄糖酸锌促进生长发育和抗氧化作用进行比较。硫酸锌、葡萄糖酸锌组小鼠的每天喂食剂量均为6.96 mg Zn/kg bw,低、中、高剂量硫酸寡糖锌组小鼠的喂食剂量分别为1.74,3.48,6.96 mg Zn/kg bw。结果表明,硫酸寡糖锌能够促进小鼠摄食量,增加体重,提高血清和肝脏中的锌含量及AKP活力,增加肝、肾、脑和睾丸质量,全面促进生长发育;降低体内MDA含量,提高SOD和T-AOC活力,表现出很好的抗氧化性。中剂量硫酸寡糖锌即可达到与葡萄糖酸锌相当的水平,高剂量硫酸寡糖锌促进缺锌小鼠生长发育及抗氧化的效果显著优于同剂量硫酸锌和葡萄糖酸锌(P<0.05)。

In order to improve the growth retardation caused by zinc deficiency,the zinc-sulfated oligosaccharide was produced by polysaccharides extracted from eucheuma.The improving effects of growth and development by zinc-sulfated oligosaccharide,zinc gluconate and zinc sulfate were compared.The dosage of zinc gluconate group and zinc sulfate group was 6.96 mg Zn/kg bw,and the dosages of zinc-sulfated oligosaccharide in low,medium and high dose group were 1.74,3.48 and 6.96 mg Zn/kg bw,respectively.The growth and development of the mice were analyzed by food intake,body weight,the zinc contents and the activity of AKP in serum and liver,and the weights of liver,kidney,brain and testis.The antioxidant effects were expressed by MDA,SOD and T-AOC in the liver.The results showed that zinc-sulfated oligosaccharide could increase food intake,body weight,the zinc contents and the activity of AKP,the weights of liver,kidney,brain and testis,which exhibited good growth and development.On the other hand,higher activity of SOD and T-AOC and lower content of MDA indicated desirable antioxidant.The effect of medium dose of zinc-sulfated oligosaccharide was similar to that of zinc gluconate,and the effect of high dose was significant higher than that of the same dose of zinc gluconate,zinc sulfate.