多囊卵巢综合征患者血清Vaspin水平及与胰岛素抵抗的相关性分析

Serum Vaspin level in patients with polycystic ovary syndrome and its relationship with insulin resistance

目的研究多囊卵巢综合征(PCOS)患者血清脂肪特异性丝氨酸蛋白酶抑制剂(Vaspin)水平及其与胰岛素抵抗的关系,探讨其临床意义。方法选取2016年1月-2018年12月浙江医院妇产科PCOS患者96例作为PCOS组,选取同期月经规律的健康女性96例作为对照组。收集两组患者年龄、体重、腰臀比(WHR)、体重指数(BMI)、空腹血糖(FPG)、空腹胰岛素(FINS)、糖化血红蛋白(HbA1c)、甘油三酯(TG)及总胆固醇(TC)等临床资料。酶联免疫吸附试验测定血清Vaspin水平。计算稳态模型胰岛β细胞功能指数(HOMA-β)和稳态模型胰岛素抵抗指数(HOMA-IR)。结果 PCOS组体重、WHR、BMI高于对照组(P <0.05)。PCOS组Vaspin、FPG、FINS、HOMA-β、HOMA-IR及TG高于对照组(P <0.05)。PCOS患者血清Vaspin水平与WHR、BMI、FINS、HOMA-IR、TG呈正相关(r=0.418、0.431、0.387、0.427和0.512,P <0.05),与体重、FPG、HOMA-β无相关性(P>0.05)。结论 PCOS患者血清Vaspin水平升高,其水平与胰岛素抵抗呈正相关。

Objective To investigate the serum lipid-specific serine protease inhibitor(Vaspin) levels and its relationship with insulin resistance in patients with polycystic ovary syndrome in order to explore its clinical significance. Methods From January 2016 to December 2018, 96 patients with PCOS were enrolled in the PCOS group and 96 patients with regular menstruation were enrolled in the control group(C group) in the Department of Obstetrics and Gynecology, Zhejiang Hospital. The age, body weight, waist-to-hip ratio(WHR), body mass index(BMI), fasting blood glucose(FPG), fasting insulin(FINS), glycosylated hemoglobin(HbA1 c), triglyceride(TG) and total cholesterol(TC) were collected. The serum Vaspin levels were determined by enzyme-linked immunosorbent assay(ELISA). The steady-state model islet β-cell function index(HOMA-β) and the steady-state model insulin resistance index(HOMA-IR) were calculated. Results The body weight, WHR and BMI of the PCOS group were higher than those of the C group(P < 0.05). The Vaspin, FPG, FINS, HOMA-β, HOMA-IR and TG in the PCOS group were higher than those in the C group(P < 0.05). The serum Vaspin level in patients with PCOS was positively correlated with WHR(r = 0.418), BMI(r = 0.431), FINS(r = 0.387), HOMA-IR(r = 0.427) and TG(r = 0.512)(P < 0.05), and was not associated with body weight, FPG and HOMA-β(P > 0.05). Conclusion The serum Vaspin level is elevated in patients with polycystic ovary syndrome, and its level is positively correlated with insulin resistance.