艾司西酞普兰治疗精神分裂症后抑郁的Meta分析

A Meta-analysis of Treatment Post-schizophrenic Depression with Escitalopram or Citalopram

目的评估艾司西酞普兰及西酞普兰治疗精神分裂症后抑郁的疗效和安全性。方法检索PubMed数据库,中国知网全文数据库,万方数据知识服务平台,中国生物医学文献数据库有关艾司西酞普兰及西酞普兰治疗精神分裂症后抑郁的随机对照研究,发表时间在2019年7月以前,设定检索词为escitalopram、citalopram、post-schizophrenic depression,艾司西酞普兰、西酞普兰、精神分裂症后抑郁,共收集文献14篇,采用Revman5软件进行Meta分析。结果 Meta分析显示,艾司西酞普兰合并抗精神病药物与单独使用抗精神病药物的8个研究具有同质性,合并效应量,差异有统计学意义,P <0.00001。西酞普兰合并抗精神病药物与单独使用抗精神病药物的6个研究具有同质性,合并效应量,差异有统计学意义,P <0.00001。不良反应的荟萃分析显示,6个关于西酞普兰合并抗精神病药物与8个关于艾司西酞普兰合并抗精神病药物的对照研究的亚组异质性检验具有同质性RR=0.91,95%CI(0.67,1.22),合并效应量差异均无统计学意义(P=0.51)。结论艾司西酞普兰及西酞普兰合并抗精神病药物治疗精神分裂症后抑郁的疗效可靠,安全。

Objective To evaluate the efficacy and safety of escitalopram or citalopram in the treatment of post-schizophrenic depression.Methods The randomized controlled trials(RCTs) about escitalopram or citalopram plus Antipsychotic drugs vs Antipsychotic drugs for post-schizophrenic depression were searched in Pubmed,CBM, CNKI and Wanfang med online before July 2019. Search terms are escitalopram,citalopram, post-schizophrenic depression. The total 14 RCTs were included.Then meta-analysis were conducted by using RevMan 5.0 soft ware. Results A total of 14 clinical trials were included in the meta-analysis. Comparing the parameters of 8 clinical trials between escitalopram plus Antipsychotic drugs vs Antipsychotic drugs,there was a homogeneity and the difference was no significant(P<0.00001). It was the same with citalopram plus Antipsychotic drugs vs Antipsychotic drugs(P <0.00001). As regards the overall adverse reaction,comparing the parameters of 14 clinical trials between escitalopram and citalopram groups, there was a homogeneity[RR=0.91, 95%CI(0.67, 1.22)] and the difference was no significant( P= 0.51). Conclusion Escitalopram or citalopram plus Antipsychotic drugs have great effects and safety on post-schizophrenic depression.