羟基乙酸联合维A酸乳膏治疗毛周角化症临床观察

Clinical Observation of Glycolic Acid Combined with Tretinoin Cream in the Treatment of Keratosis Pilaris

目的:评价羟基乙酸联合0.025%和0.1%维A酸乳膏治疗毛周角化症的临床疗效及安全性。方法:纳入毛周角化症患者20例,采用随机开放自身对照法分为羟基乙酸联合维A酸乳膏治疗组和维A酸乳膏单一治疗组,联合治疗组每4周治疗1次,4~6次为1个疗程。治疗前和最后1次治疗4周后由同一医生对同一患者皮损评估并拍照,记录患者皮损消退情况。结果:联合治疗组有效率55%,单一治疗组有效率30%,两组有效率比较具有统计学意义(P<0.01);联合治疗组满意率55%,单一治疗组满意率20%,两组满意率比较具有统计学意义(P<0.05)。联合治疗组不良反应为在治疗中出现轻度烧灼痒刺感、红斑、结霜,治疗结束冷敷30min后缓解,术后有3例出现干燥、脱屑,发生率为15%,外用保湿霜后均缓解,其余未见明显不良反应;单一治疗组不良反应为干燥、脱屑,发生率为75%,外用保湿霜后均缓解。结论:羟基乙酸联合维A酸乳膏治疗毛周角化症安全有效,满意度高。

Objective To evaluate the clinical efficacy and safety of glycolic acid combined with 0.025% and 0.1% tretinoin cream in the treatment of keratosis pilaris.Methods Twenty patients with keratosis pilaris were enrolled in this study.They were randomly divided into two groups:glycolic acid combined with tretinoin cream treatment group and tretinoin cream single treatment group.The combined treatment group was treated once every 4 weeks intervals treatment sessions were 4-6.Before treatment and 4 weeks after the last treatment,the same doctor assessed and photographed the lesions of the patient,and recorded the regression of the lesions.Results 55% patients in the treatment group respond to therapy,and that of the single treatment group was 30%,The effective rate of the two groups was statistically significant (P<0.01).The satisfaction rate of combined therapy was 55%,and that of single treatment side was 20%.There was significant difference between the two groups(P<0.05).The adverse reactions in the combined treatment group were mild burning,itching,erythema and frosting in the treatment.After 30 minutes of ice compress,the adverse reactions were relieved.3 cases of dry and desquamation occurred in the postoperative combined treatment group,the incidence was 15%.All cases were relieved after external application of moisturizing cream,and no other obvious adverse reactions were observed.The adverse reactions in the single treatment group were dry and desquamation,the incidence rate was 75%,and the topical moisturizing cream was relieved.Conclusion Glycolic acid combined with tretinoin cream is safe and effective in the treatment of keratosis pilaris.