窄谱强脉冲光联合重组人表皮生长因子凝胶治疗面部痤疮瘢痕疗效分析

Analysis of Curative Effect of Narrow Band Intense Pulsed Light Combined with Recombinant Human Epidermal Growth Factor Gel on Facial Acne Scar

目的:探讨窄谱强脉冲光联合重组人表皮生长因子凝胶治疗面部痤疮瘢痕的临床疗效。方法:选取2017年2月-2018年3月笔者医院收治的80例面部痤疮瘢痕患者,随机分为对照组与观察组,每组40例。对照组给予窄谱强脉冲光照射治疗,观察组在对照组基础上给予重组人表皮生长因子凝胶涂抹。对比两组临床疗效,比较结痂持续时间、痂皮脱落时间及治疗后痤疮瘢痕权重评分(clinical evaluation scale for acnescarring,ECCA),观察不良反应发生情况及治疗前后的痤疮特异性生活质量量表(Acne-specific Quality of Life Questionnaire,Acne-QOL)评分,并统计随访3个月患者复发率。结果:两组临床疗效等级分布比较差异具有统计学意义(P<0.05),观察组总有效率高于对照组,差异具有统计学意义(P<0.05);观察组结痂持续时间与痂皮脱落时间均短于对照组,观察组治疗后ECCA评分小于对照组,差异均具有统计学意义(P<0.05);观察组治疗后总不良反应发生率低于对照组,差异具有统计学意义(P<0.05);两组治疗后Acne-QOL量表中社会功能、自我认知、情感功能及痤疮症状评分均高于治疗前,观察组治疗后Acne-QOL量表各维度评分均高于对照组,差异均具有统计学意义(P<0.05);随访3个月,两组复发率差异无统计学意义(P>0.05)。结论:窄谱强脉冲光联合重组人表皮生长因子凝胶虽未能有效预防痤疮瘢痕复发,但可明显改善面部痤疮瘢痕患者临床症状,提高疗效,缩短结痂与痂皮脱落时间,并可减轻不良反应及提高患者生活质量。

Objective To explore the clinical efficacy of narrow band intense pulsed light combined with recombinant human epidermal growth factor gel on facial acne scar.Methods 80 patients with facial acne scar were selected from February 2017 to March 2018 in our hospital,who were divided into reference group and observation group randomly,with 40 cases in each group.The reference group was treated with narrow band intense pulsed light irradiation,while the observation group was given recombinant human epidermal growth factor gel smear on the basis of the reference group.The clinical effects of the 2 groups were compared,and the scab duration time,scab skin shedding time and the scores of clinical evaluation scale for acnescarring (ECCA) after treatment were compared,then the adverse reactions were observed and the Acne-specific Quality of Life Questionnaire (Acne-QOL) scores before and after treatment were compared,and the recurrence rates of follow-up 3 months were also counted.Results There was significant difference in the grade distributions of the clinical efficacy between the 2 groups (P<0.05),and the total effective rate of the observation group was higher than that of the reference group,and the difference was statistically significant (P<0.05).The time of scab formation duration and time of scab skin shedding of the observation group were shorter than those of the reference group,and the ECCA score of the observation group after treatment was lower than that of the reference group,and the differences were statistically significant (P<0.05).The incidence rate of total adverse reactions of the observation group after treatment was lower than that of the reference group,and the difference was statistically significant (P<0.05).The scores of social function,self-cognition,emotional function and acne symptoms of the Acne-QOL scale of the 2 groups after treatment were significantly higher than those before treatment,of which the observation group after treatment were significantly higher than those of the reference group,and the differences were statistically significant (P<0.05).During the follow-up period of 3 months,there was no significant difference in recurrence rate between the 2 groups (P>0.05).Conclusion Narrow band intense pulsed light combined with recombinant human epidermal growth factor gel does not effectively prevent recurrence,but it can significantly improve the clinical symptoms of patients with facial acne scar,improve the therapeutic effect,shorten the scab formation time and scab skin shedding time,reduce adverse reactions and improve the quality of life,which has the values of popularization and application.