圣草酚药理作用研究进展

Advances in studies on pharmacological effects of eriodictyol

圣草酚是一种广泛存在于蔬菜、水果及中药中的天然二氢黄酮类化合物,具有抗氧化、抗炎、抗肿瘤及神经保护等多种药理活性,常用于治疗气喘、过敏性鼻炎、风湿等疾病。近年来,随着国内外研究的深入,发现圣草酚的药理作用同参与调控核因子E2相关因子2(Nrf2)、核转录因子-κB(NF-κB)、蛋白激酶B(PKB/Akt)等细胞信号通路有关。对圣草酚的药理作用研究进展进行综述,以期为其进一步研究、开发和利用提供参考。

Eriodictyol is a natural flavonoid which is abundant in vegetables,fruits and some Chinese medicines with many pharmacological effects such as anti-oxidation,anti-inflammatory,antitumor and neuroprotection.It has been used in the treatment of asthma,allergic rhinitis,rheumatism and other diseases frequently.With the deeper research on eriodictyol,the mechanism of its pharmacological effect has been found to be involved in nuclear factor erythroid-2-related factor 2(Nrf2),nuclear transcription factor-κB(NF-κB),and protein kinase B(PKB/Akt)signal pathways.In this paper,we summarize the recent research progress on pharmacological effects of eriodictyol,with purpose to offer reference in further research,development and utilization.