间充质干细胞诱导巨噬细胞极化促进创面愈合的研究进展

Promotion of wound healing via regulating the polarization of macrophage by mesenchymal stem cells

如何促进复杂创面快速愈合、减少瘢痕增生是整形外科领域迫切需要解决的问题。间充质干细胞(MSCs)是当前细胞治疗的研究热点,具有多向分化潜能,控制炎症及促进修复的作用。作者通过复习文献,对MSCs通过释放可溶性细胞因子,调节巨噬细胞极化特性,使其向抗炎型M2细胞极化,减少炎症因子释放,激活组织修复和再生功能的机制进行总结,认为间充质干细胞对巨噬细胞的极化作用为解决创面愈合难题提供了新的治疗策略和理论依据。

How to promote rapid wound healing and reduce scar hyperplasia is an urgent problem to be solved in plastic surgery.Mesenchymal stem cells(MSCs)is a research hotspot in current cell therapy.The author reviewed the literature and summarized the mechanism of the MSCs effect on the macrophage.MSCs release multiple soluble cytokines,leading the polarization of anti-inflammatory type M2 cell which can reduce the inflammatory cytokines and promote tissue repair and regeneration.The writer concluded that the polarization effect of mesenchymal stem cells on macrophages provides a new therapeutic strategy and theoretical basis for solving the problem of wound healing.