中药有效成分及配伍抗缺血性脑损伤诱导的神经血管单元损伤作用机制研究进展

Research Progress of Effective Components of Traditional Chinese Medicine and Its Compatibility Against Neurovascular Unit Injury Induced by Ischemic Brain Injury

脑缺血再灌注损伤(CIRI)是指在缺血基础上恢复血流后组织损伤反而加重,甚至发生不可逆性损伤的一种病理现象,是包含了神经元损伤、血-脑屏障破坏、胶质细胞损伤、血管损伤等的综合体。随着神经血管单元(NVU)概念的提出,CIRI在临床治疗和试验研究上也从单一结构走过渡到了整体。旨在对以往文献的整理、分类、汇总、归纳等相关工作的基础上,对中药有效成分在CIRI引起的NVU损伤中的作用及其机制进行综述,以期吸取以往研究的经验,为进一步深入研究提供新思路,为临床应用提供理论依据。

Cerebral ischemia reperfusion injury(CIRI)refers to a pathological phenomenon that tissue damage is aggravated even irreversibly after the recovery of blood flow on the basis of ischemia.It is a complex including neuron injury,blood-brain barrier destruction,glial cell injury and vascular injury.As the concept of neural vascular unit(NVU)was proposed,CIRI has been transformed from a single structure to a whole in clinical treatment and experimental research.This paper aims to summarize the function and mechanism of the active ingredients of traditional Chinese medicine in NVU injury caused by CIRI on the basis of previous literature review,classification,summary and induction,so as to draw on the previous research experience,provide new ideas for further research as well as theoretical basis for clinical application.