肌肉减少症对老年2型糖尿病患者全身体成分及生活质量的影响

Effect of sarcopenia on total body composition and quality of life in elderly patients with type 2 diabetes

目的探讨肌肉减少症对老年2型糖尿病(type 2 diabetes, T2DM)患者全身体成分及生活质量的影响。方法选取2018年1月至2019年6月就诊于解放军联勤保障部队第900医院65岁以上的T2DM患者78例。根据欧洲老年肌少症工作组(European Working Group on Sarcopenia in Older People, EWGSOP)诊断标准,将患者分为肌少症组和非肌少症组,比较两组在全身体成分及生活质量的差异。结果共筛查出肌少症患者24例(30.8%),其中男16例(66.7%),女8例(33.3%)。肌少症组体质量[(57.08±9.48)kg比(66.02±10.73)kg]、BMI[(21.53±2.13)kg/m2比(26.48±3.20)kg/m2]、体脂百分比[(26.15±5.48)%比(30.99±5.02)%]、脂肪指数[(5.62±1.36)%比(8.32±1.99)%]、内脏脂肪面积[(85.20±36.91)cm^2比(112.22±33.09)cm^2]、四肢骨骼肌指数[(6.00±0.85)kg/m2比(6.94±1.02)kg/m2]、Barthel指数[(58.90±8.50)分比(78.30±5.50)分]均低于非肌少症组,差异均有统计学意义(P <0.05),肌少症组年龄高于非肌少症组[(78.04±5.74)岁比(74.17±7.07)岁,P <0.05]。结论与非肌少症糖尿病患者相比,肌少症患者的年龄更大,BMI更低,其肌肉质量、力量、部分体成分指标及生活质量也明显下降。

Objective To investigate the effect of sarcopenia on total body composition and quality of life in elderly patients with type 2 diabetes(T2 DM). Methods Elderly T2 DM patients(over 65 years old, n = 78) were enrolled in our hospital from January 2018 to June 2019. According to the European Working Group on Sarcopenia in Older People(EWGSOP),patients were divided into sarcopenia group and control group. The differences in body composition and activities of daily living between the two groups were compared. Results A total of 24 cases(30.8%) were diagnosed in the Sarcopenia group.There were 16 males(66.7%) and 8 females(33.3%). Body weight [(57.08 ± 9.48) kg vs.(66.02 ±10.73) kg], BMI [(21.53 ±2.13) kg/m2 vs.(26.48 ± 3.20) kg/m2], body fat percentage [(26.15 ± 5.48) % vs.(30.99 ± 5.02) %], fat mass index [(5.62 ±1.36)% vs.(8.32 ± 1.99)%], visceral fat area [(85.20 ± 36.91) cm^2 vs.(112.22 ± 33.09) cm^2], limb muscle index [(6.00 ± 0.85)kg/m2 vs.(6.94 ± 1.02) kg/m^2] and Barthel index [(58.90 ± 8.50) vs.(78.30 ± 5.50)] were lower in the sarcopenia group than those in the control group(P all < 0.05). Age was higher in the sarcopenia group than that in the control group [(78.04 ±5.74) years vs.(74.17 ± 7.07) years, P<0.05]. Conclusions Compared with patients with non-sarcopenia diabetes patients,sarcopenia patients are older and have lower BMI, and their muscle mass, strength, some body composition indicators and quality of life have also decreased significantly.