摘要
Wüstite-type Fe(0.78)Mn(0.22)O nanocubes,with a uniform size of^10 nm in edge length,have been synthesized by thermal-decomposition approach.The nanocubes exhibited superparamagnetic properties at room temperature,associated with a magnetization of 12.6 emu/g.These Fe(0.78)Mn(0.22)O nanocubes present transversal(r2)and longitudinal(r1)relaxivities of 325.9 and 0.518 mM^-1 s^-1 at 7 T for water protons.The ratio of the r2/r1(629.2)ranks them being the highest sensitivity(r2/r1)comparable to currently reported T2-weighted magnetic resonance imaging(MRI)agents.Meanwhile,the Fe(0.78)Mn(0.22)O nanocubes were functionalized and demonstrated to be biocompatible when attached to the surface of mesenchymal stem cells,therefore showing the promise as a new class of MRI agents in clinic applications.
Wüstite-type Fe0.78Mn0.22O nanocubes,with a uniform size of～10 nm in edge length,have been synthesized by thermal-decomposition approach.The nanocubes exhibited superparamagnetic properties at room temperature,associated with a magnetization of 12.6 emu/g.These Fe0.78Mn0.22O nanocubes present transversal（r2） and longitudinal（r1） relaxivities of 325.9 and 0.518 mM-1 s-1 at 7 T for water protons.The ratio of the r2/r1（629.2） ranks them being the highest sensitivity（r2/r1） comparable to currently reported T2-weighted magnetic resonance imaging（MRI） agents.Meanwhile,the Fe0.78Mn0.22O nanocubes were functionalized and demonstrated to be biocompatible when attached to the surface of mesenchymal stem cells,therefore showing the promise as a new class of MRI agents in clinic applications.
基金
supported financially by the National Natural Science Foundation of China (Nos.51471045,51401049 and 51471048)
the National 1000-Plan for Young Scholars and the Start-up Funding from the Northeastern University of China
the Fundamental Research Funds for the Central Universities (No. N160208001)
