摘要
Six new trichilin-type limonoids(1-6)with C-19/29 lactol or acetal bridge and a new ring intact limonoid(7)were isolated from the desiccative ripe fruits of Trichilia sinensis.Their structures were determined by extensive spectroscopic methods including 1 H NMR,13 C NMR,HSQC,HMBC,ROESY experiments as well as HRESI-MS data.All isolated compounds were evaluated for toxicities against human pulmonary carcinoma A549 and Hela cell lines by sulforhodamine B(SRB)method.Compound 7 showed weak inhibitory activity in Hela cell line at 40μmol·L^-1.
Six new trichilin-type limonoids(1-6) with C-19/29 lactol or acetal bridge and a new ring intact limonoid(7) were isolated from the desiccative ripe fruits of Trichilia sinensis. Their structures were determined by extensive spectroscopic methods including 1 H NMR, 13 C NMR, HSQC, HMBC, ROESY experiments as well as HRESI-MS data. All isolated compounds were evaluated for toxicities against human pulmonary carcinoma A549 and Hela cell lines by sulforhodamine B(SRB) method. Compound 7 showed weak inhibitory activity in Hela cell line at 40 μmol·L-1.
基金
supported by the National Natural Science Foundation of China(No.31470416)
the Outstanding Youth Fund of the Basic Research Program of Jiangsu Province(No.BK20160077)
the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT_15R63)
