摘要
Four new corynanthe-type alkaloids,meloslines C–F(1–4),together with four known ones(5–8)were isolated from the roots of Alstonia scholaris.Their structures including absolute configurations were elucidated by extensive spectroscopic analysis and electronic circular dichroism(ECD)calculation.Compounds 1 and 2 exhibited potent vasorelaxant activity on endothelium-intact renal arteries precontracted with KCl.
Four new corynanthe-type alkaloids, meloslines C–F(1–4), together with four known ones(5–8) were isolated from the roots of Alstonia scholaris. Their structures including absolute configurations were elucidated by extensive spectroscopic analysis and electronic circular dichroism(ECD) calculation. Compounds 1 and 2 exhibited potent vasorelaxant activity on endothelium-intact renal arteries precontracted with KCl.
基金
supported by the National Key R&D Program of China(No.2017YFC1703802)
the National Natural Science Foundation of China(Nos.U1801287,81630095,and 81803398)
the Science and Technology Planning Project of Guangdong Province(No.2018B020207008)
the High-performance Super Computing Platform of Jinan University
