摘要
Two new folate-derived analogues,named uncarophyllofolic acids A(1)and B(2),respectively,were isolated from the Uncaria rhynchophylla hook bearing stem(Gouteng in Chinese).The distinct stereochemical structures of 1 and 2 were determined by spectroscopic data analysis in combination with acidic hydrolysis and Marfey’s derivatization,along with comparison of their specific rotation and Cotton effect(CE)data with those of the biogenetically related known derivatives as well as theoretical calculations of electronic circular dichroism(ECD)spectra.A plausible biosynthetic pathway of 1 and 2,associating to folate metabolism and the previously reported orychophragines A-C from Orychophragmus violaceus,is discussed.
Two new folate-derived analogues, named uncarophyllofolic acids A(1) and B(2), respectively, were isolated from the Uncaria rhynchophylla hook bearing stem(Gouteng in Chinese). The distinct stereochemical structures of 1 and 2 were determined by spectroscopic data analysis in combination with acidic hydrolysis and Marfey’s derivatization, along with comparison of their specific rotation and Cotton effect(CE) data with those of the biogenetically related known derivatives as well as theoretical calculations of electronic circular dichroism(ECD) spectra. A plausible biosynthetic pathway of 1 and 2, associating to folate metabolism and the previously reported orychophragines A-C from Orychophragmus violaceus, is discussed.
基金
supported by the National Natural Sciences Foundation of China(Nos.81630094,21732008,and 81730093)
CAMS Innovation Fund for Medical Science of China(Nos.2017-I2M-3-010 and 2016-I2M-1-010)
the Drug Innovation Major Project(No.2018ZX09711001-001-001)
