摘要
Phytochemical investigation of the leaves and twigs of Callicarpa cathayana led to the isolation of six new clerodane diterpenoids,cathayanalactones A-F(1-6),together with seven analogues(7-13).Their structures were established by extensive NMR analyses together with experimental and calculated ECD spectra analyses.Compounds 1,2,3,7 and 11 showed inhibitory activities on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.
Phytochemical investigation of the leaves and twigs of Callicarpa cathayana led to the isolation of six new clerodane diterpenoids, cathayanalactones A-F(1-6), together with seven analogues(7-13). Their structures were established by extensive NMR analyses together with experimental and calculated ECD spectra analyses. Compounds 1, 2, 3, 7 and 11 showed inhibitory activities on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.
基金
supported by Yunnan Applicative and Basic Research Program(Nos.2018FY001 and 2018FA048)
the National Natural Science Foundation of China(Nos.81422046,81860615 and 21762048)
the Foundation of Yunnan Educational Committee(No.2018JS002)
the Natural Science Foundation of Yunnan University(No.2017YDQN03)
the Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education(No.2017KF02)
the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT_17R94)
Project of Innovative Research Team of Yunnan Province to XIAO Wei-Lie
