变应性鼻炎鼻分泌物嗜酸性粒细胞与肺功能相关性研究

Correlation between the eosinophil count in the nasal secretions and pulmonary function in patients with allergic rhinitis

目的研究单纯性变应性鼻炎(AR)患者发作及稳定期鼻分泌物嗜酸性粒细胞(Eos)含量与肺功能的相关性。方法选取成年单纯性AR患者102例为AR组,53名健康体检者为对照组,应用肺功能仪及鼻分泌物涂片检测AR组发作期、稳定期及对照组各项肺功能指标和鼻分泌物Eos计数。结果对照组及AR患者发作期、稳定期检测的鼻腔分泌物Eos计数及肺功能指标PEF、MEF75、FEV1均存在差异,差异有统计学意义(P<0.001);AR患者发作期、稳定期鼻分泌物Eos计数与自身PEF,FEV1,MEF75具有相关性,其中与FEV1呈显著相关(r=-0.53,P<0.001)。结论AR患者鼻腔分泌物Eos计数与肺功能关系密切,大部分AR患者存在着不同程度的基础肺功能损害,且随着气道变态反应加重,肺功能下降明显。

Objective We aimed to study the correlation between the eosinophil(Eos)content in the nasal secretions and pulmonary function in patients with simple allergic rhinitis(AR)during the attack and stable period.Methods Overall,102 adults with simple AR were included in the AR group,and 53 healthy individuals were included in the control group.We used pulmonary function tests to determine the pulmonary function indexes;nasal secretion smears were prepared,and the Eos count was determined during the attack and stable period.Result There were significant differences in the Eos count in the nasal secretions and peak expiratory flow(PEF),maximal expiratory flow at 75%of the forced vital capacity(MEF75),and forced expiratory volume in one second(FEV1)between the control group and AR group during the attack and stable period(P<0.001).The Eos count in the nasal secretions of the patients in the AR group during the attack and stable period was correlated with PEF,FEV1,and MEF75,and was significantly correlated with FEV1(r=-0.53,P<0.001).Conclusion We showed that the Eos count in the nasal secretions of patients with AR was closely related to pulmonary function.With the aggravation of airway allergy,pulmonary function decreased significantly.