管腔内pH监测在反流性疾病中的应用

Utility of intraluminal pH monitoring in reflux diseases

反流性疾病包括为食管反流病(GERD)和咽喉反流性疾病(LPRD),两者虽在发病机制及表现上有所不同,但均指胃内容物向上反流导致的疾病。GERD尤其是LPRD/胃食管气道反流性疾病其临床症状缺乏特异性,且体征往往不完全与疾病严重程度相符,临床实践中做出正确诊断并不容易。pH监测可以客观直接监测食管或咽喉部酸碱度变化,克服了通过主观症状诊断的非特异性,其在反流性疾病诊断中的意义不言而喻,论文对管腔内pH监测的发展历程和其特点进行综述。

Reflux diseases such as gastroesophageal reflux disease(GERD)and laryngopharyngeal reflux disease(LPRD)are caused by upward reflux of gastric contents,but differ in pathogenesis and manifestations.The clinical symptoms of GERD,especially LPRD,are non-specific;therefore,it is difficult to correctly diagnose these diseases in clinical practice.However,pH changes in the esophagus or throat can be objectively and directly monitored to circumvent diagnoses based on the non-specific subjective symptoms,and therefore can be used in the diagnosis of reflux diseases.Here,we review the developmental processes and characteristics of intraluminal pH monitoring.