肝内胆管癌的靶向治疗研究进展

Progress of targeted therapy of intrahepatic cholangiocarcinoma

肝内胆管癌(ICC)发病率逐年上升,但多数患者确诊时已无手术切除机会。常规化疗和放疗对ICC患者长期生存率的提高并不理想,患者总体预后较差。近年来,随着对胆道系统恶性肿瘤分子机制的深入了解,确立了一些与ICC发病机制相关的关键基因和信号通路,从而为靶向治疗指明方向。本文就ICC重要分子机制及靶向治疗作一综述。

The incidence of intrahepatic cholangiocarcinoma(ICC)has been increasing year by year.For most patients,surgical resection is not suitable when they are diagnosed as ICC.Conventional chemotherapy and radiotherapy are not effective for the long-term survival rate of ICC patients and lead to the poor overall prognosis.In recent years,with the deepening understanding about the molecular mechanism of biliary malignant tumors,some key genes and signaling pathways related to the pathogenesis of ICC have been identified,providing new ideas for the targeted therapy.In this paper,major molecular mechanisms and targeted therapies of ICC are reviewed.