人表皮生长因子受体-2表达与结直肠癌临床病理特征及预后的关系

Expression of HER-2 in colorectal cancer and its relationship with clinicopathological features and prognosis

目的分析人表皮生长因子受体-2(HER-2)在结直肠癌组织中的表达水平及其与结直肠癌患者的临床病理特征及预后的关系。方法回顾性分析2006年1月至2015年12月在广东省人民医院手术治疗的1463例结直肠癌患者的临床资料,采用免疫组化方法检测其肿瘤组织中HER-2表达,并分析其与患者的临床病理特征及预后的关系。结果1463例结直肠癌组织中HER-2(-)711例(48.6%),HER-2(+)470例(32.1%),HER-2(++)249例(17.0%),HER-2(+++)33例(2.3%)。HER-2表达与肿瘤分化程度和肿瘤浸润深度T分期有关(P<0.05),而与患者的性别、年龄、肿瘤部位、N分期、M分期、TNM分期、总生存期及无疾病生存期均无关(均P>0.05)。结论HER-2表达与肿瘤分化程度和生长浸润有关,但不能作为预测结直肠癌患者预后的指标。

Objective To investigate the correlation between the expression of(epidermal growth factor receptor-2,HER-2)and clinicopathological features and survival of colorectal cancer.Methods From Jan 2005 to Dec 2015,all colorectal cancer cases were enrolled that the expression levels of HER-2 were detected in Guangdong Provincial People's Hospital.Clinicopathological features of the tumors and survival of the patients were analyzed.Results A total of 1463 cases were collected in 10 years,including 711 cases(4&6%)of HER-2(-),470 cases(32.1%)of HER-2(+),249 cases(17%)of HER-2(++),and 33 cases(2.3%)of HER-2(+++).Correlation analysis shows that the expression levels of HER-2 were significantly correlated with tumor differentiation and the depth of tumor invasion(T stage),but not correlated with gender,age,tumor location,N stage,M stage,TNM stage and overall survival,and disease-free survival.Conclusion The expression of HER-2 may be related to tumor differentiation and growth infiltration,but it cannot be used as a predictor of prognosis in patients with colorectal cancer.