模式生物斑马鱼在中药药效物质筛选中的应用进展

Application progress on model organism zebrafish in screening of pharmacodynamic substances of Chinese materia medica

与哺乳动物相比,斑马鱼在药物药效筛选方面具有独特的优势,目前已受到医药学界越来越多的重视。近年来,对斑马鱼的探索已延伸和扩展到中药领域,特别是对我国具有多靶点、多途径、多环节作用的传统单味中药、复方和中成药等药效物质的筛选。作为一种完整的动物模型,斑马鱼可以对中药中发挥作用的有效化学成分进行全方面、深层次的研究,进而实现对中药药效物质进行便捷、快速和高通量的筛选。结合国内外近5年文献报道,综述了模式生物斑马鱼在中药药效物质筛选方面的最新研究进展,主要从筛选心血管药物、调脂保肝药物、抗骨质疏松药物、抗肿瘤药物、抗炎药物和其他药物6个方面和独特优势进行归纳总结,以期为模式生物斑马鱼在中药中的应用研究提供新的思路,以及为研究人员在中药新药研究方面提供借鉴参考。

Compared with mammals,zebrafish has unique advantages in screening pharmacoactive substance,and has been paid more and more attention in the field of medicine.In recent years,the exploration of zebrafish has been extended and extended to the field of Chinese materia medica(CMM),especially for the screening pharmacoactive substance of the single CMM,the CMM compound and Chinese patent medicines with multi-target,multi-channel and multi-link effects.As a complete animal model,zebrafish can carry out comprehensive and deep research on the effective chemical components that play a role in TCM,and then realize convenient,rapid and high-throughput screening of pharmacodynamics substances in CMM.Combined with the literature reports in recent five years at home and abroad,this paper reviews the latest research progress and unique advantages on the screening of pharmacodynamics substances in CMM in model organism zebrafish,mainly from the screening of cardiovascular drugs,lipid-lowering and liver-protecting drugs,anti-osteoporosis drugs,anti-tumor drugs,anti-inflammatory and other drugs,in order to provide a new idea for the application of model organism zebrafish in CMM and provide reference for the new drugs research of CMM.