桉属间苯三酚-萜烯类化合物及其抗肿瘤作用机制研究进展

Research progress on phloroglucinol terpenes from Eucalyptus genus and their antitumor mechanism

间苯三酚-萜烯为桉属Eucalyptus L.Herit植物中天然存在的主要活性成分,具有独特的聚酮-二萜骨架,抗癌活性显著,是抗癌先导化合物的潜在来源。综述桉属植物抗癌活性天然间苯三酚-萜烯类化合物的结构、作用机制,为间苯三酚-萜烯类抗癌新药的研发提供参考。

Phloroglucinol terpenes are the mainly naturally active ingredients from Eucalyptus genus.Based on the modern pharmacological studies,phloroglucinol terpenes with unique polyketoditerpenoid skeleton have been confirmed to have the anticancer activity,which could be the important source to find the novel potential anticancer lead compounds.In this article,the structure,antitumor mechanism and activity of these known phloroglucinol terpenes from Eucalyptus genus were reviewed,which can provide the references for the following researches on the novel anticancer drugs of phloroglucinol terpenes.