丁苯酞注射液对脑梗死急性期患者脑血流灌注与认知功能的影响

Effect of butylphthalide injection on cerebral blood perfusion and cognitive function in patients with acute cerebral infarction

目的观察脑梗死急性期应用丁苯酞注射液对患者脑血流灌注以及认知功能的影响。方法选取2018年2月至2018年12月洛阳市第六人民医院脑梗死急性期并伴有认知功能障碍的患者60例为研究对象。应用数字随机法将其分为对照组与观察组,每组30例。对照组接受常规治疗,观察组在常规治疗基础上应用丁苯酞注射液治疗。比较治疗前后两组患者认知功能情况、脑血流灌注情况。结果接受治疗前两组患者脑血流灌注指标及认知功能评分差异未见统计学意义(P>0.05),治疗后观察组认知功能显著优于对照组(P<0.05),脑血流灌注指标与对照组比较差异有统计学意义(P<0.05)。结论对脑梗死急性期患者应用丁苯酞注射液,可有效改善患者脑血流灌注,提高患者认知功能,应用价值显著。

Objective To observe the effects of butylphthalide injection on cerebral blood perfusion and cognitive function in patients with acute cerebral infarction. Methods Sixty patients with acute cerebral infarction in the Sixth People’s Hospital of Luoyang from February to December 2018 were enrolled in this study. The patients were divided into the control group and the observation group by digital random method, with 30 cases in each group. The group received routine treatment. The observation group was treated with butylphthalide injection on the basis of conventional treatment. The cognitive function and cerebral blood perfusion of the two groups were compared before and after treatment. Results There were no significant differences in cerebral blood perfusion indexes or cognitive function scores between the two groups before treatment(P>0.05). After treatment, the cognitive function of the observation group was significantly better than that of the control group(P<0.05). There were significant differences in the cerebral blood perfusion indexes between the two groups(P<0.05). Conclusions The application of butylphthalide injection in patients with acute cerebral infarction can effectively improve the cerebral blood perfusion and improve cognitive function of patients, and its application value is significant.