多潘立酮联合乳酶生治疗小儿功能性消化不良的临床效果

Clinical effect of domperidone combined with lactase on functional dyspepsia in children

目的分析多潘立酮联合乳酶生治疗功能性消化不良(FD)的效果。方法选取2019年1月至2019年6月在郑州大学附属儿童医院治疗的90例FD患儿为研究对象,分为对照组与观察组,每组45例。对照组使用多潘立酮治疗;观察组在对照组治疗基础上联合使用乳酶生治疗。比较两组治疗后症状评分、治疗总有效率、不良反应发生情况。结果治疗后,观察组患儿的各症状评分明显低于对照组(P<0.05);观察组患儿的治疗总有效率(97.78%,44/45)高于对照组(84.44%,38/45),差异有统计学意义(P<0.05);观察组不良反应发生率(8.89%,4/45)低于对照组(24.44%,11/45),差异有统计学意义(P<0.05)。结论多潘立酮联合乳酶生用药方案可显著改善患儿临床症状,提高治疗有效率,且不良反应较少,具有良好的有效性及安全性。

Objective To analyze the effect of domperidone combined with lactase on functional dyspepsia(FD).Methods Ninety children with FD treated in Children’s Hospital Affiliated to Zhengzhou University from January 2019 to June 2019 were selected as the study subjects.They were divided into control group and observation group, with 45 cases in each group.The control group was treated with domperidone.The observation group was treated with lactase on the basis of the control group.The symptom score, total effective rate and adverse reactions after treatment were compared between the two groups.Results After treatment,the scores of symptoms in the observation group were significantly lower than those in the control group(P<0.05).The total effective rate of the observation group(97.78%, 44/45) was higher than that of the control group(84.44%, 38/45), the difference was significant(P<0.05).The incidence of adverse reactions in the observation group(8.89%, 4/45) was lower than that in the control group(24.44%, 11/45), the difference was significant(P<0.05). Conclusions Domperidone combined with lactase can significantly improve the clinical symptoms of children, improve the treatment efficiency, and reduce adverse reactions, with good effectiveness and safety.