摘要
六氟异丙醇(HFIP)本身具有独特的性质,近些年来在有机反应中得到了广泛应用,尤其在碳碳成键反应当中,如:Friedel-Crafts烷基化反应,Friedel-Crafts酰基化反应,Micheal加成反应,多烯串联环化反应等。本文主要对HFIP的性质以及其在碳碳成键反应中的相关应用进行综述,为该天然产物、药物碳骨架的构建提供指引。
Hexafluoroisopropanol(HFIP) has unique properties and has been widely used in organic reactions in recent years,especially in carbon-carbon bonding reactions,such as:Friedel-Crafts alkylation,Friedel-Crafts Acylation reaction,Micheal addition reaction,Cation-Olefin Polycyclizations reaction.This paper reviews the properties of HFIP and its related applications in carbon-carbon bonding reactions,and provides guidance for the construction of this natural product and drug carbon skeleton.
作者
田岩
吴长州
刘秋雨
孙晓冉
孔宪强
Tian Yan;Wu Changzhou;Liu Qiuyu;Sun Xiaoran;Kong Xianqiang(Pharmaceutical Department,Changzhou Vocational Institute of Engineering,Changzhou 213164,China;Jiangsu Jiaerke Pharmaceuticals Group,Changzhou 213164,China;School of Chemistry and Bioengineering,Donghua University,Shanghai 200051,China)
出处
《山东化工》
CAS
2019年第24期40-42,共3页
Shandong Chemical Industry
基金
常州工程职业技术学院校科研基金(11130300118013)、常州工程职业技术学院博士科研启动基金
