摘要
目的研究白介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)联合白介素-6(IL-6)对胃癌的诊断价值。方法选择240例胃癌患者为观察组,240例体检健康者为对照组。比较2组的血清IL-1β、TNF-α以及IL-6水平,并观察血清IL-1β、TNF-α以及IL-6水平与胃癌临床病理参数的关系。结果观察组的血清IL-1β、TNF-α以及IL-6水平明显高于对照组(P <0. 05)。血清IL-1β、TNF-α以及IL-6水平与胃癌患者的临床分期(Ⅰ~Ⅱ期、Ⅲ~Ⅳ期),分化程度(中高分化、低分化),淋巴结转移(有、无)有关系(P <0. 05)。结论胃癌患者的血清IL-1β、TNF-α以及IL-6表达水平较高,联合检测3种血清标志物有助于评估胃癌患者的疾病进展及预后情况。
Objective To study the diagnostic value of IL-1β、TNF-α combined with IL-6 in gastric cancer. Methods Selected 240 cases of patients with gastric cancer who were treated as the observation group,240 healthy patients as the control group. Serum levels of IL-1 beta,TNF-alpha and IL-6 were compared between the 2 groups. The relationship between serum levels of IL-1β、TNF-α and IL-6 and clinicopathological parameters of patients with gastric cancer was observed. Results The serum levels of IL-1 beta,TNF-alpha and IL-6 in the observation group were significantly higher than those of the control group( P <0. 05). Serum levels of IL-1β、TNF-α and IL-6 were correlated with clinical stage( stage Ⅰ ~ Ⅱ,stage Ⅲ ~ Ⅳ),degree of differentiation( moderate to high differentiation,low differentiation) and lymph node metastasis( with or without) of gastric cancer( P <0. 05). Conclusion The serum levels of IL-1β、TNF-α and IL-6 in patients with gastric cancer are high. The combined detection of three serum markers is helpful to evaluate the disease progression and prognosis of patients with gastric cancer.
作者
董志强
刘美荣
任秀梅
DONG Zhiqiang;LIU Meirong;REN Xiumei(Dongchangfu People's Hospital,Liaocheng,252000)
出处
《实用癌症杂志》
2020年第1期28-30,共3页
The Practical Journal of Cancer