吉西他滨联合奥沙利铂介入栓塞治疗原发性肝癌对缺氧诱导因子-1α的影响

Effect of Gemcitabine combined with Oxaliplatin on Hypoxia-inducible Factor-1α in the Intervention Embolization for Primary Liver Cancer

目的探讨吉西他滨联合奥沙利铂介入栓塞治疗原发性肝癌对缺氧诱导因子-1α的影响。方法将原发性肝癌患者60例,随机分为两组:一组吉西他滨联合奥沙利铂介入栓塞治疗组(A组,30例),一组盐酸吡柔比星为主介入栓塞治疗组(B组,30例),统计分析两组患者的临床疗效、血清肿瘤标志物水平、不良反应发生情况。结果A组患者的总缓解率显著高于B组,差异有统计学意义(P<0.05)。两组患者治疗后的血清VEGF、GP73、HIF-1α水平均显著低于治疗前,差异有统计学意义(P<0.05);治疗后A组患者的血清VEGF、GP73、HIF-1α水平均显著低于B组,差异有统计学意义(P<0.05)。A组患者的腹泻、神经毒性发生率显著高于B组,差异有统计学意义(P<0.05),血小板减少、中性粒细胞减少、总胆红素升高发生率显著低于B组,差异有统计学意义(P<0.05)。结论吉西他滨联合奥沙利铂介入栓塞治疗原发性肝癌较盐酸吡柔比星为主介入栓塞治疗更能有效降低患者的血清缺氧诱导因子-1α水平。

Objective To explore the effect of gemcitabine combined with oxaliplatin on hypoxia-inducible factor-1αin the intervention embolization for primary liver cancer.Methods 60 patients with primary liver cancer were randomly selected,who were divided into 2 groups.Group A was the gemcitabine combined with oxaliplatin interventional embolization treatment group(30 cases),and group B was the pirilobicin hydrochloride interventional embolization treatment group(30 cases).The clinical efficacy,serum tumor markers and toxicity of the 2 groups were statistically analyzed.Results The total remission rate of group A were significantly higher than that of group B(P<0.05).Serum VEGF,GP73 and HIF-1αlevels were significantly lower of the 2 groups after treatment than before treatment(P<0.05);After treatment,serum VEGF,GP73 and HIF-1αlevels of group A were significantly lower than those of group B(P<0.05).The incidence of diarrhea and neurotoxicity in group A were significantly higher than that of group B(P<0.05),The incidence of thrombocytopenia,neutropenia and increased total bilirubin in group A were significantly lower than group B(P<0.05).Conclusion The gemcitabine combined with oxaliplatin in the intervention embolization for primary liver cancer is more effective than the pirilobicin hydrochloride interventional embolization in reducing serum hypoxia-inducible factor-1αlevels of patients.