CA125水平在支气管扩张患者中的表达及临床意义

目的 探讨支气管扩张患者中血清CA125以及TNF-α、IL-8相关炎症因子水平的变化及其临床意义.方法 选取2016年1月至12月浙江舟山市普陀区人民医院呼吸内科住院的支气管扩张患者89例,根据血清CA125水平分为CA125升高组和正常组,比较两组间的血清CA125水平和年龄、性别、病程以及其他检验指标的差异.其中CA125升高组患者治疗后予以复查相关指标,比较治疗前后的水平差异,以及CA125正常组与CA125升高组治疗后组间的差异,并进一步分析影响血清CA125的因素.结果 89例支气管扩张患者中血清CA125升高者35例,CA125水平为54.90(35.28~160.30)U/ml;血清CA125正常组54例,CA125水平为18.73(5.78~34.92)U/ml.两组间对比在血清CA125、TNF-α、IL-8、白细胞(WBC)、C反应蛋白(CRP)水平差异均存在统计学意义(P<0.05),而年龄、性别、病程差异均无统计意义(P>0.05).CA125升高组治疗前后以及治疗后与CA125正常组两两比较,其中治疗前后组自身对照CA125、WBC、CRP、TNF-α、IL-8,差异均有统计学意义(P<0.05).治疗后与正常组相比,血清CA125仍异常升高,余指标无差异.相关分析表明CA125与白细胞、CRP和TNF-α呈正相关(P<0.05),进一步多元逐步回归分析显示CRP、TNF-α是CA125的独立影响因素.结论 支气管扩张患者中血清CA125、TNF-α水平升高,CRP、TNF-α是其独立影响因素,升高组治疗后与正常组相比,血清CRP、TNF-α、IL-8均无统计学差异,血清CA125虽较治疗前下降,但仍显著高于正常组,提示存在其他因素参与CA125的升高.

Objective To study the clinical significance of determination of serum CA125,TNF,IL-8 in patients with bronchiectasis.Methods The clinical data of 89 patients with bronchiectasis in Zhejiang Putuo Hospital from January 2016 to December 2016 were coDected in the study.The patients were divided into CAI25 elevated group and CAI25 normal group according to serum CAI25 levek,and the difference of semm CAI25,age,gender,disease duration and other test indicators were compared between two groups.Some indicators were re-examined in CAI25 elevated group,and the difference between the elevated group pre—therapy and post—therapy was determined,and the factors involved serum CAI25 were fiirther analyzed.Results Among 89 patients with bronchiectasis,semm CAI25 level was increased in 35 cases,CAI25 level was 54.90(35.28—160.30)U/ml;serum CAI25 level was 18.73(5.78~34.92)U/ml in 54 cases of normal group.There were significant differences in serum CAI25,TNF-a,IL-8,white blood cells and CRP between the two groups(P<0.05),bur there were no significant differences in age,sex and course of disease(P>0.05).CAI25 elevated group was compared with CAI25 nonnal group before and after treatment.There were significant differences in CAI25,WBC,CRP,TNF—α and IL—8 before and after treatment(P<0.05).Compared with the normal group,serum CAI25 was still abnormally elevated after treatment,and there was no difference in other indicators.The correlation analysis showed that CAI25 was positively correlated with leukocytes,CRP and TNF—α(P<0.05).Further multiple stepwise regression analysis showed that CRP and TNF—α were independent influencing factors of CA125.Conclusion The serum levels of CAI25,TNF-α rise in patients with bronchiectasis,CRP and TNF-α are an independent associated factors of serum CAI 25 level.The level of semm CAI 25 in elevated group post-therapy is still significantly higher than CA125 normal group,suggesting other factors involved the increase of CA125.