嘉兴地区女童中枢性性早熟情况调查与分析

目的 调查嘉兴地区女童中枢性性早熟情况,分析中枢性性早熟的影响因素,并提出预防对策和建议.方法 选取于2016年3月至2017年10月期间在本院确诊的187例女性中枢性性早熟儿童和200例正常女童为观察对象.利用体格检查、实验室分析判定性成熟,并采用自制问卷形式进行调查和分析.结果 中枢性性早熟组与正常组的身高、体重、骨龄、卵巢容积、子宫容积相比,差异具有统计学意义(P<0.05).中枢性性早熟组与正常组女童的年龄、BMI指数、有无开灯睡觉、是否服用营养品、饮食习惯、家庭年收入、母亲文化程度、母亲初潮年龄,差异具有统计学意义(P<0.05).多因素logistic回归分析结果显示,母亲初潮年龄、服用营养品、母亲学历、饮食习惯、BMI指数是嘉兴市女童中枢性性早熟的独立影响因素.结论 中枢性性早熟的病因机制较为复杂,对多个影响因素开展合理的干预能够有效减少中枢性性早熟的发生率.

Objective To investigate the Central Precocious Puberty of female children,analyze the influencing factors of precocious puberty,and put forward preventive measures and suggestions.Methods From march 2016 to 2017,10 in our hospital 187 cases of central female precocious children and 200 normal female children were selected as the research objects.The use of physical examination,laboratory analysis of the decisive maturity,and the use of self-made questionnaire survey to conduct investigations and analysis.Results There was significant difference between the central precocious puberty group and the normal group in height,weight,bone age,ovarian volume and uterine volume(P<0.05).Age,BMI index,sleep time without light,nutrition status,eating habits,annual family income,mother's education level,maternal menarche age,precocious puberty in siblings,etc.had significant difference in precocious group and normal group(P<0.05).Multivariate logistic regression analysis showed that maternal menarche age,taking nutritional products,maternal education,eating habits and BMI were the independent influencing factors of Central Precocious Puberty in female children.Conclusion The etiology of central precocious puberty is complex,and reasonable intervention of multiple influencing factors can effectively reduce the incidence of central precocious puberty.