经导管肝动脉化疗栓塞联合微波消融治疗消化道肿瘤肝转移的疗效分析

Efficacy analysis of transcatheter arterial chemoembolization combined with microwave ablation in the treatment of gastrointestinal tumor with liver metastasis

目的分析经导管肝动脉化疗栓塞(TACE)联合微波消融治疗消化道肿瘤肝转移的临床疗效。方法选取消化道肿瘤肝转移患者40例作为研究对象,按照随机数字表法分为观察组和对照组,每组20例。观察组接受TACE联合微波消融治疗;对照组接受TACE治疗。比较两组患者的临床疗效,治疗前后T细胞亚群的变化以及治疗后3、6、12个月的生存率。结果观察组治疗总有效率高于对照组(P<0.05)。治疗后,观察组CD8+水平显著下降,CD3^+、CD4^+、CD4^+/CD8+均显著上升(均P<0.05);观察组上述指标与对照组比较,差异均有统计学意义(均P<0.05)。观察组12个月的生存率明显高于对照组(P<0.05)。结论TACE联合微波消融治疗消化道肿瘤肝转移的疗效显著,可明显改善机体免疫功能,提高患者术后生存率,值得临床推广。

Objective To analyze the clinical efficacy of transcatheter arterial chemoembolization(TACE)combined with microwave ablation in the treatment of gastrointestinal tumor with liver metastasis.Methods A total of 40 patients with liver metastasis from gastrointestinal tumor were selected and divided into observation group or control group according to the random number table method,with 20 cases in each group.The observation group received TACE combined with microwave ablation,while the control group received TACE treatment.The clinical efficacy,the change of T cell subsets before and after treatment,and the survival rate at the time of 3,6 and 12 months after treatment were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).The level of CD8+in the observation group decreased significantly after treatment,while CD3^+,CD4^+,CD4^+/CD8+increased significantly(all P<0.05);meanwhile,there were statistically significant differences between the two groups in the abovementioned indexes after treatment(all P<0.05).The twelve-month survival rate was significantly higher in the observation group than in the control group(P<0.05).Conclusion TACE combined with microwave ablation is effective in the treatment of gastrointestinal tumor with liver metastasis,for it can prominently improve the body immune function,and increase the survival rate of patients after operation,indicating it is worthy of clinical promotion.