旋覆理血汤改善2型糖尿病脾虚气郁型老年抑郁患者的疗效观察

Observation on the Efficacy of Xuanfu Lixue Decoction on Senile Depression Patients with Type 2 Diabetes with Spleen Deficiency and Qi Stagnation

目的:观察旋覆理血汤治疗2型糖尿病脾虚气郁型老年抑郁患者的效果。方法:选取2016年10月至2018年10月上海市普陀区人民医院收治的2型糖尿病脾虚气郁型老年抑郁患者80例作为研究对象,按照信封法随机分为对照组和观察组,每组40例。对照组采用基础糖尿病治疗联合丙咪嗪治疗4周,观察组采用基础糖尿病治疗联合旋覆理血汤治疗4周。比较2组疗效、抑郁自评量表(SDS)评分、中医症候积分、血糖指标、生命质量和不良反应差异。结果:观察组治疗有效率高于对照组(P<0.05)。观察组治疗后SDS评分、中医症候积分、糖化血红蛋白(HbA1c)水平、糖尿病患者生命质量特异性量表(DSQL)总分、不良应发生率低于对照组(P<0.05),空腹血糖(FPG)、餐后2 h血糖(2 hPG)水平与对照组差异无统计学意义(P>0.05)。结论:旋覆理血汤可显著改善2型糖尿病脾虚气郁型老年抑郁患者抑郁状态和临床症状,并有助于稳定血糖,提高生命质量。

Objective:To observe the effects of Xuanfu Lixue Decoction on senile depression patients with type 2 diabetes of spleen deficiency and qi stagnation.Methods:A total of 80 elderly patients with type 2 diabetes with spleen deficiency and qi stagnation were randomly divided from Oct 2016 to Oct 2018 into control group(40 cases)was treated with basic diabetes treatment combined with imipramine for 4 weeks,and the observation group(40 cases)was treated with basic diabetes treatment combined with Xuanfu Lixue Decoction for 4 weeks.The therapeutic effects of the 2 groups were compared.The efficacy,SDS score,TCM syndrome score,blood glucose index,quality of life and adverse reactions were compared between the 2 groups.Results:The effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,SDS score,TCM syndrome score,HbA1 c level,total score of DSQL and incidence of adverse reactions in the observation group were lower than those in the control group(P<0.05),but fasting plasma glucose(FPG)and 2-h postprandial plasma glucose(2 hPG)were not significantly different from the control group(P>0.05).Conclusion:Xuanfu Lixue Decoction can significantly improve the depression and clinical symptoms of senile depression patients with type 2 diabetes of spleen deficiency and qi stagnation,and help to stabilize blood sugar and improve the quality of life.