不同临床分期肺鳞状细胞癌患者血清及BALF中肿瘤标志物水平变化及动态检测的意义被引量：3

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摘要目的:分析不同临床分期肺鳞状细胞癌患者血清及支气管肺泡灌洗液(BALF)中鳞状细胞癌相关抗原(SCC)、细胞角蛋白19片段(CYFRA 21–1)、癌胚抗原(CEA)水平变化及动态检测临床意义。方法:选取2015年1月至2018年5月洛阳市第一人民医院收治的60例肺鳞状细胞癌患者,肿瘤分期(TNM)T分期Ⅰ期12例,Ⅱ期11例,Ⅲ期19例,Ⅳ期18例,均给予手术、化疗等综合治疗,对比治疗前不同临床分期血清及BALF中SCC、CYFRA 21–1、CEA水平,并比较治疗前后血清SCC、CYFRA 21–1、CEA水平。结果:BALF中SCC、CYFRA 21–1、CEA水平高于血清,差异具有统计学意义(P<0.05);Ⅲ~Ⅳ期血清及BALF中SCC、CYFRA 21–1、CEA水平均高于Ⅰ~Ⅱ期,差异具有统计学意义(P<0.05);治疗后,血清中SCC、CYFRA 21–1、CEA水平低于治疗前,差异具有统计学意义(P<0.05)。结论:肺鳞状细胞癌患者临床分期越高,血清及BALF中SCC、CYFRA 21–1、CEA水平越高,监测其水平有助于疗效评估,且BALF中肿瘤标志物水平对诊断肺鳞状细胞癌参考价值优于血清。

作者王磊

机构地区洛阳市第一人民医院

出处《深圳中西医结合杂志》 2019年第22期77-78,共2页 Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

关键词肺鳞状细胞癌细胞角蛋白19片段支气管肺泡灌洗液癌胚抗原鳞状细胞癌相关抗原

分类号 R734.2 [医药卫生—肿瘤]

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