期刊文献+

辅助生殖技术中选择性单胚胎移植的研究进展 被引量:6

Research progress of selective single embryo transfer in assisted reproductive technology
下载PDF
导出
摘要 辅助生殖技术(assisted reproductive technology, ART)已成为不孕症患者最有效的治疗方法,但多胎妊娠为其最突出的并发症之一。多胎妊娠常引起羊水过多、先兆子痫、低体质量儿、贫血等多项严重的母婴并发症。避免多胎妊娠的方法是单胚胎移植,选择性单胚胎移植已经成为生殖医学未来的发展方向,单胚胎的选择为临床难题。如何保证临床妊娠率又显著降低各类并发症?对于35岁以下的卵巢储备功能正常患者或有优质囊胚的高龄患者,可通过检测其胚胎发育过程中的代谢产物、胚胎持续监测或植入前遗传学诊断,筛选最具发育潜能的胚胎进行移植,改善临床结局。本文通过文献回顾,探讨选择性单胚胎移植的临床应用前景。 Assisted reproductive technology(ART) has become the most effective treatment for infertility patients, but multiple pregnancy is one of the prominent complications. Multiple pregnancies often cause serious maternal and child complications such as polyhydramnios, pre-eclampsia, low birth weight, and anemia. The single embryo transfer is the method to avoid multiple pregnancy, and selective single embryo transfer has become the development direction of reproductive medicine. It ensures the clinical pregnancy rate with reduction of various complications. For patients under 35 years of age with normal ovarian reserve or older patients with high-quality blastocysts, the screening can be performed by detecting metabolites or continuously monitoring embryos or preimplantative genetic diagnosis during embryonic development, so that the potential embryos can be transplanted to improve clinical outcomes. This article reviews the recent progress on the clinical application of selective single embryo in assisted reproduction technology.
作者 王明雯(综述) 童晓文 王炎秋 纪亚忠(审校) WANG Ming-wen;TONG Xiao-wen;WANG Yan-qiu;JI Ya-zhong(Reproductive Medical Center,Tongji Hospital,Tongji University School of Medicine,Shanghai 200065,China;Tongji University School of Medicine,Shanghai 200092,China)
出处 《同济大学学报(医学版)》 CAS 2019年第6期890-895,共6页 Journal of Tongji University(Medical Science)
基金 上海市科学与技术委员会重点实验室项目(17DZ2273600) 同济大学中央高校基本科研业务费专项资金(22120170059)
关键词 辅助生殖技术 选择性单胚胎移植 多胎妊娠 临床结局 assisted reproductive technology elective single embryo transfer multiple pregnancy clinical outcomes
  • 相关文献

参考文献9

二级参考文献79

  • 1Jurisicova A, Casper RF, MacLusky NJ, et al. HLA-G expression during preimplantation human embryo development[J]. Proc Natl Acad Sci U S A,1996.93:161-165.
  • 2Yao YQ. Barlow DH. Sargent IL. Differential expression of alternatively spliced transcripts of human leukocyte antigen-G in single human preimplantation embryos and inner cell masses[J]. J Immunology, 2005 , 175: 8379-8385.
  • 3Fuzzi B. Rizzo R. Criscuoli Lvet al. HLA-G expression in early embryos is a fundamental prerequisite for the obtainment of pregnancy[J]. Eur J Immunol,2002,32:311-31S.
  • 4Zhu YJ ,Zhao SJ .Zhao nx.? al Gene expression profiles of HLAG 1 overexpressed in hES cells [J]. Biochem Genet, 2012, SO: 809-82l.
  • 5Sun LL, Han YB, Chen JH, et al. Down-regulation of HLA-G boosted natural killer cell-mediated cytolysis in JEG-3 cells cultured in vitro[J]. Fertil Steril , 2008,90: 2398-240S.
  • 6Zhu YJ .Zhao HX, Wang L, et al. DA neurons derived from hES cells that express HLA-G 1 are capable of immunosuppression[J]. Brain Res,2012,1437:134-142.
  • 7Guo Y,Lee CL,So KH,et al. Soluble human leukocyte antigen-gf activates extracellular signal-regulated protein kinase signaling and stimulates trophoblast vasion[J]. PLoS One,2013,8:e76023.
  • 8Sun LL, Wang AM, Haines CJ, et al. Down-regulation of HLA-G attenuates cleavage rate in human triploid embryos[J]. J Reprod Infertil , 2011 , 12: 215-220.
  • 9Wang JM, Zhao HX , Wang L, et al. The human leukocyte antigen G promotes trophoblast fusion and 13- hCG production through the Erk1/2 pathway in human choriocarcinoma cell lines[J]. Biochem Biophys Res Commun,2013,434:460-46S.
  • 10Zhu XM, Han T, Wang XH, et al. Overexpression of miR-1S2 leads to reduced expression of human leukocyte antigen-G and increased natural killer cell mediated cytolysis in JEG-3 cells[J]. Am J Obstet Gynecol,202:592. el-7.

共引文献37

同被引文献47

引证文献6

二级引证文献24

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部