铁代谢紊乱与肝癌的研究进展

Research progress on iron metabolism disorder and liver cancer

铁元素是许多含铁酶及含血红素酶活性的关键因子,在细胞增殖、代谢、解毒等过程中扮演着重要角色。铁进出细胞及其发挥生物学作用均涉及二价铁和三价铁之间的转换,过量的铁催化产生活性氧(ROS),造成DNA损伤、脂质过氧化、蛋白质变性,导致致突变、致癌效应。机体内过多的铁主要储存在肝细胞,越来越多的证据表明,肝铁过负荷是原发性肝癌的危险因素。现从铁过负荷与肝癌发生的关系、肝癌发生过程中铁含量及铁代谢的变化及作用、铁作为靶点在肝癌治疗中的应用3个方面的研究进展进行综述。

Iron is a key factor for the activities of iron-containing enzymes and heme-containing enzyme,playing important roles in cell proliferation,metabolism,and detoxification.The transport of iron and its participation in the enzyme activities are involved in the conversion between Fe2+and Fe3+,which could induce the reactive oxygen species(ROS)if excess,causing DNA damage,lipid peroxidation and protein denaturation,leading to mutagenesis and carcinogenesis.The excess iron is mainly stored in the hepatocytes.Increasing evidences show that hepatic iron overload is an independent risk factor for primary hepatocellular carcinoma.Thus,the present review focused the following three aspects:the relationship between iron-overload and hepatocarcinoma,the alterations of iron metabolism and its effects during the development of hepatocarcinoma,and the treatment of hepatocarcinoma targeting iron-related molecules.