幽门螺旋杆菌与胃溃疡的致病关系

The relationship between Helicobacter pylori and gastric ulcer

胃溃疡(gastric ulcer,GU)是世界上发病率和患病率不断上升的主要胃肠疾病之一,被认为是一个全球性的健康问题,即便有很多人研究,但其具体发病机制尚不完全清楚。幽门螺杆菌(Helicobacter pylori,HP)是定植于人类胃黏膜上皮细胞的微需氧型细菌。全世界近80%~90%的GU是由HP感染引起的,HP感染是造成GU发病率的最大危险因素。本文对HP与GU的致病关系进行综述,以便国内外的学者对其进行更深入的了解,同时也为进一步研究提供帮助。

Gastric ulcer(GU)is one of the main gastrointestinal diseases with increasing incidence and prevalence in the world.It is considered to be a global health problem.Even though there have been many studies,the specific pathogenesis is not completely clear.Helicobacter pylori(HP)is a microaerobic bacterium colonized in human gastric mucosal epithelial cells.Nearly 80%~90%of GU is caused by HP infection in the world,and HP infection is the biggest risk factor for the incidence of GU.In this paper,the pathogenicity relationship between HP and GU are reviewed,so that the scholars at home and abroad can get a better understanding of the relationship and provide help for further research.