促红细胞生成素在自发性蛛网膜下腔出血中的治疗作用

Therapeutic effect of erythropoietin on spontaneous subarachnoid hemorrhage

蛛网膜下腔出血(subarachnoid hemorrhage,SAH)占所有脑血管意外的6%~8%,具有较高的致死率和致残率,严重危害人类健康。虽然可以通过手术或血管内治疗得到有效控制,但迟发性脑缺血却仍然有较高的发生率,仍是蛛网膜下腔出血的主要并发症和致死原因。自促红细胞生成素(Erythropoietin,EPO)及其受体在中枢神经系统发现以来,大量证据表明促红细胞生成素在脑中具有抗细胞凋亡、抗炎、抗氧化应激、促进神经发生、促进脑血管生成、营养神经等作用,它是作为一种保护因子存在于脑组织中的,具有很大潜在的神经保护作用。

Subarachnoid hemorrhage(SAH)accounts for 6% to 8% of all cerebrovascular accidents(CVA),with high mortality and disability rate,and seriously threaten human health.Although it can be effectively controlled by surgery or intravascular therapy,delayed cerebral ischemia still has a high incidence,which is still the main complication and cause of death of subarachnoid hemorrhage.Since erythropoietin(erythropoietin,EPO)and its receptors in the central nervous system have been found,many evidences have shown that erythropoietin has a series of functions,such as anti-apoptosis,anti-inflammatory,anti-oxidation stress,promoting neurogenesis and promoting cerebrovascular generated,nerve nutrition etc.It exists as a protective factor in the brain and has a big potential nerve protective effect.