尾叶香茶菜的化学成分及其对酪氨酸酶抑制活性的研究

Study on chemical constituents and tyrosinase inhibition activity of Isodon excisa (Maxin.) Hara

利用正、反相色谱等分离技术对长白山区药用植物尾叶香茶菜的甲醇提取液进行分离,得到了5个化合物.经波谱鉴定各化合物分别为野鸦椿酸(1)、1-羟基松脂素(2)、川藏香茶菜甲素(3)、兰萼香茶菜甲素(4)和咖啡酸甲酯(5),其中化合物5为首次在该植物中分离得到,化合物3和5对酪氨酸酶具有一定的抑制作用,其抑制率分别为51.5%和55.0%.

Five compounds were isolated from the methanol extract of the medicinal plant Isodon excisa(Maxin.) Hara in Changbai mountain area by normal phase and reversed phase chromatography. Euscaphic acid(1), 1-hydroxy-pinoresinol(2), pseurata A(3), glaucocalyxin A(4) and caffeic acid methyl ester(5) were identified by spectroscopic methods. Compound 5 is isolated from Isodon genus for the first time. Compound 3 and 5 showed slight inhibitory effect for the tyrosinase activity, inhibition rate is 51.5% and 55.0%, respectively.