清金化痰汤对慢性阻塞性肺疾病患者气道炎症反应和黏液高分泌的影响

Effect of Qingjin Huatan Decoction on Airway In?ammation and Mucus Hypersecretion in Chronic Obstructive Pulmonary Patients

目的从抑制炎症反应和气道黏液高分泌探讨清金化痰汤对慢性阻塞性肺疾病急性加重期的作用机制。方法符合慢性阻塞性肺疾病急性加重(AECOPD)入选标准患者41例,通过随机数字法分为观察组和对照组,2组患者均给予西医常规抗感染、维持血流动力学、器官功能维护等对症支持治疗,观察组在此基础上加用中药清金化痰汤口服或鼻饲。比较2组患者的中医证候评分(TCMSS)变化;分别于第1天、第7天采集患者血浆,测定2组患者治疗前后血浆中炎症介质肿瘤坏死因子(TNF-a)、白介素lp(IL-lp)和黏蛋白5AC(MUC5AC)水平的变化。结果观察组在临床疗效、中医证候积分及血清学指标方面,均优于对照组。结论清金化痰汤在抑制气道炎症反应及气道黏液高分泌方面有一定的疗效。

Objective To explore the mechanism of Qingjin Huatan decoction on acute exacerbation of chronic obstructive pulmonary disease(COPD)by inhibiting inflammatory reaction and airway mucus hypersecretion.Methods Forty-one patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)were randomly divided into observation group and control group.The patients in both groups were given routine anti・infection treatment,hemodynamics maintenance and organ function maintenance,on this basis,the observation group was given oral Qingjin Huatan decoction or nasal feeding.The changes of TCM Symptom Score(TCMSS)were compared between the two groups,and the plasma was collected on the 1st and 7th day respectively Plasma levels of inflammatory Tumor necrosis factors(TNF-a),interleukin-ip(IL-lp)and MUC5AC(MUC5AC)were measured before and after treatment.Results The clinical effect,TCM Symptom score and serological index of the observation group treated with Qingjin Huatan decoction were better than those of the control group.Conclusion Qingjin Huatan decoction is effective in inhibiting airway inflammation and mucus hypersecretion.