阿奇霉素不同给药方案治疗儿童急性鼻窦炎的疗效观察

Observation on efficacy of different administration regimens of azithromycin on acute sinusitis in children

目的观察阿奇霉素不同给药方案治疗儿童急性鼻窦炎的临床疗效。方法 60例急性鼻窦炎患儿,随机分为观察组和对照组,各30例。观察组患儿口服阿奇霉素,给药3 d,停4 d;对照组患儿连续口服阿奇霉素。观察比较两组患儿治疗7、14 d后的临床疗效以及患儿不良反应(腹泻、恶心、腹痛、食欲差)发生情况。结果观察组患儿治疗7、14 d后的临床总有效率分别为86.67%、93.33%,对照组患儿治疗7、14 d后的临床总有效率分别为90.00%、93.33%,两组比较差异无统计学意义(P>0.05)。观察组治疗7、14 d后不良反应发生率分别为13.33%、16.67%,低于对照组的16.67%、30.00%,但差异无统计学意义(P>0.05)。结论阿奇霉素治疗儿童急性鼻窦炎,服3 d停4 d的服药法与1次/d服法的疗效相当,间歇的服药方法更容易为患儿和家长接受,且副作用较小。这种简便的服法值得临床推广应用。

Objective To observe the clinical efficacy of different administration regimens of azithromycin on acute sinusitis in children.Methods A total of 60 children with acute sinusitis were randomly divided into observation group and control group,with 30 cases in each group.The observation group took azithromycin orally for 3 d and stopped for 4 d,and the control group took azithromycin continuously.The clinical efficacy and occurrence of adverse reactions(diarrhea,nausea,abdominal pain,poor appetite)after 7 and 14 d of treatment was observed and compared between the two groups.Results There was no statistically significant difference in clinical efficacy after 7 and 14 d of treatment between the two groups(P>0.05).After 7 d of treatment,the observation group had 1 case of diarrhea,1 case of nausea,1 case of abdominal pain,0 case of poor appetite.The control group had 1 case of diarrhea,2 cases of nausea,1 case of abdominal pain,1 case of poor appetite.After 14 d of treatment,the observation group had 1 case of diarrhea,2 cases of nausea,0 case of abdominal pain,2 cases of poor appetite.The control group had 2 cases of diarrhea,3 cases of nausea,1 case of abdominal pain,3 cases of poor appetite.The incidence of adverse reactions after 7 and 14 d of treatment in the observation group was a little lower than those in the control group,but the difference was not statistically significant(P>0.05).Conclusion For the treatment of children with acute sinusitis,drug therapy of taking azithromycin for 3 d,stopped for 4 d shows equal efficacy with once a day of drug therapy.Intermittent medication is more easily accepted by children and parents,with less side effects.This kind of simple and convenient administration is worthy of clinical promotion.